DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and slc6a22.1

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_005166076.1	Gene:	slc6a22.1 / 368923	ZFINID:	ZDB-GENE-030616-629	Length:	584	Species:	Danio rerio

Alignment Length:	605	Identity:	290/605 - (47%)
Similarity:	401/605 - (66%)	Gaps:	36/605 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ELGHTTSLQ----SSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPY 86
            |:.|...||    .|...:.:|..|.|:        ||.||||::|||:|.|..|||||||||||
Zfish     2 EIQHDPDLQFKLAYSDAQSNETGLKTQI--------RGQWSSKVEFILAVAGQIIGLGNVWRFPY 58

  Fly    87 LCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWM 150
            ||||||||.|.:||::.||..|||:|.||.||||..:.|.:..: ||.|:|:|:||.:.|:..:.
Zfish    59 LCYKNGGGVFFIPYVVFLFACGIPLFLMETALGQYTSQGSVTCWRKICPLFEGLGYGSQVVVLYS 123

  Fly   151 NVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSA 215
            :.|||:|||||.||.|.|...::||.:|.||||:.||| :::|..                  .|
Zfish   124 SAYYIIILAWAFFYLFSSFSGELPWASCRNWWNSENCV-EFDRMQ------------------GA 169

  Fly   216 LNITSL-ELTDPVKEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVY 279
            .|::.: ..:.|||||||||.|.|:..:.|:|::|||||..|||.|::||||:|||||.||||||
Zfish   170 KNLSFMANASSPVKEFWERRVLNITGSVNELGSVRWELALCLLLAWVICYFCVWKGVKSTGKVVY 234

  Fly   280 FTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVAL 344
            |||.||||:|.:||:||:|||||::||.||:.||.::|.:.:||:||.||||:||.|.:|.|.||
Zfish   235 FTATFPYVMLMVLLIRGLTLPGAIDGITFYLYPNPARLADPQVWMDAGTQIFYSYALCIGCLTAL 299

  Fly   345 GSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSA 409
            |||||:.||.|||.:.:|.:||.||..|||.||||:||||.||...::.||.|||||||:.||.|
Zfish   300 GSYNKYNNNCYKDCVYLCLLNSGTSFVAGFAIFSVLGFMALEQGVDISVVAESGPGLAFIAYPRA 364

  Fly   410 VLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQ--LLRKRKEIFIAIVCALSYLV 472
            |..:|.:.:||..||.|::|:||||:|..:|..:|||.|..|.  |...|:::|:.::|...:|:
Zfish   365 VAMMPMAQLWSICFFLMIILLGLDSEFVGLESLMTAITDMNPNFFLQGHRRKLFLLVICIACFLI 429

  Fly   473 GLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFC 537
            ||..:|:||:|:||:.|.|:.||..||.....:.:.|.|.||.||.|:.|.|||||:|....|:|
Zfish   430 GLLMVTEGGLYVFQLFDYYSCSGMTLLLFAIAQSICIGWFYGADRLYENIADMIGYHPLTLMKYC 494

  Fly   538 WCVTTPAICLGVFFFNIVQWTPVKYLD-YSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGEL 601
            |...||.:|:|.|.|::|::||:|:.: |.||||.:|.||:..|||.|.:|::|.:....|||.|
Zfish   495 WKYITPIVCIGTFIFSLVKFTPLKFNNTYEYPWWGYAAGWWFTLSSTLLVPIWMIYAILVTPGTL 559

  Fly   602 SEKIRALVRIDEDVTRLREK 621
            .:::|.|.....|:....|:
Zfish   560 KQRLRVLCTPASDLPLTSER 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	280/557 (50%)
slc6a22.1	XP_005166076.1	SLC6sbd-TauT-like	30..569	CDD:271387	280/557 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820