Protein Alignment Gat and SLC6A19

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001003841.1
• Gene: SLC6A19 / 340024
• HGNCID: 27960
• Length: 634
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 220/646 - (34%)
• Similarity: 316/646 - (48%)
• Gaps: 119/646 - (18%)

  Fly    33 LQSSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFI 97
            |.:..|:..:....:|    |:...|..|.:|..::|:.:|..:||||||||||||..:|||||:
Human    11 LDARIPSLAELETIEQ----EEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFM 71

  Fly    98 LPYIITLFLAGIPMFFMELALGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWA 161
            :|::|.|.|.|||:.::|.|:||.|..|.|||: .|.|..||:|.|:.:.|..:.:||..|::|.
Human    72 IPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWI 136

  Fly   162 VFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDP 226
            ::|.|.|.:..:||..|....|....|.:..|                              :.|
Human   137 MWYLFNSFQEPLPWSDCPLNENQTGYVDECAR------------------------------SSP 171

  Fly   227 VKEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTI 291
            |..||.|..|.||..|.:.|:|:|.:...|...|.:.|.|..:|::.|||.||.|:..|||:|||
Human   172 VDYFWYRETLNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTI 236

  Fly   292 LLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYK 356
            .|:||:||.||..||.|...||.::|...:.|:||..|:|||:.|..|.|::..|||...||..|
Human   237 FLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEK 301

  Fly   357 DALIVCTVNSSTSMFAGFVIFSVIGFMAHE--------------------------------QQR 389
            |::||..:|..||::...|::|||||.|.:                                |||
Human   302 DSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQR 366

  Fly   390 -----PVA---------DV------AASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDS 434
                 |.|         |:      |..|.||||:|:..|:.::|.||:||.|||.||..:||.|
Human   367 CNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSS 431

  Fly   435 QFCTMEGFITAIID------EWPQLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAV 493
            .|..|||.:..:.|      :||      ||:...::|..::|:|.......|.|...:|||||.
Human   432 MFGNMEGVVVPLQDLRVIPPKWP------KEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAG 490

  Fly   494 SGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVF-FFNIVQ- 556
            | ..||.:.|.|..|:.:.||||||...|:.|||:.|.::|:..|.|.:|.:.|.:| ||.:|:
Human   491 S-IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEV 554

  Fly   557 --------WTP-----VKYLDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRT----PGE 600
                    |.|     .|....|||.|.:......|....|.||.|..:...|.    ||:
Human   555 SQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGYAIYKLIRNHCQKPGD 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	216/621 (35%)
SLC6A19	NP_001003841.1	SLC5-6-like_sbd	32..612	CDD:444915	214/616 (35%)