DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and Slc6a6

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_008761345.1	Gene:	Slc6a6 / 29464	RGDID:	61912	Length:	631	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	312/558 - (55%)
Similarity:	400/558 - (71%)	Gaps:	20/558 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQ 120
            |.|..||||:||:|||.|..:||||||||||||||||||||::||.|.||.:|:|:||:|:.:||
  Rat    49 PQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEVIIGQ 113

  Fly   121 MLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNT 184
            ..:.||:..: ||.|:|.|||||:.|:...:|||||||||||.:|.|.|.:.|:||..||:.|||
  Rat   114 YTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFQSFQKDLPWAHCNHSWNT 178

  Fly   185 VNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQISHGIEEIGNIR 249
            ..|:....|:|...|           .|:||.|.||     ||.|||||..|.:|.||:..|:::
  Rat   179 PQCMEDTLRRNESHW-----------VSLSAANFTS-----PVIEFWERNVLSLSSGIDHPGSLK 227

  Fly   250 WELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNF 314
            |:||..|||||::|:|||||||:.|||||||||.||:.:|.:|||||:|||||.||||||:.||.
  Rat   228 WDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPNI 292

  Fly   315 SKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSV 379
            |:|.:.:|||||.|||||||.:.||.:.:||||||:..|.|:|.:::..:||.||..:||.|||:
  Rat   293 SRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSI 357

  Fly   380 IGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFIT 444
            :||||.||...:||||.|||||||:.||.||..:|....||.|||.||||:||||||..:||.||
  Rat   358 LGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQIT 422

  Fly   445 AIIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECV 507
            :::|.:|..|||  |:||||||||::|||:|||.:|:||||:||:.|.||.||.||||:.||||.
  Rat   423 SLVDLYPSFLRKGYRREIFIAIVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECF 487

  Fly   508 SISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YSYPWWA 571
            .|:|.||.|..||||:|||||.|..|.|:.|.|.|||:|:|.|.|::|::.|:.|.. |.||.||
  Rat   488 VIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFIFSLVKYVPLTYNKVYRYPDWA 552

  Fly   572 HAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALV 609
            ...||..|||||:.|||.:..|..||.|.|..:|:.|:
  Rat   553 IGLGWGLALSSMVCIPLVIVILLCRTEGPLRVRIKYLI 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	311/556 (56%)
Slc6a6	XP_008761345.1	SLC5-6-like_sbd	51..592	CDD:382020	311/556 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820