DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and Slc6a18

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_058859.2	Gene:	Slc6a18 / 29323	RGDID:	69352	Length:	615	Species:	Rattus norvegicus

Alignment Length:	633	Identity:	227/633 - (35%)
Similarity:	317/633 - (50%)	Gaps:	115/633 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAG 108
            |....||.||.  :|..|.:|:.::||.:|.|:||||:|||||||:.:|||||::||.|.|...|
  Rat     5 SGMDPLVDIED--ERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCHTHGGGAFLIPYFIALVFEG 67

  Fly   109 IPMFFMELALGQMLTIGGLGVFK-IAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRAD 172
            ||:|::|||:||.|..|.:||:| |:|...|:|.....:|..:::||..||.|.:::|..|.:..
  Rat    68 IPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTILLWVLWFFLNSFQHP 132

  Fly   173 VPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQ 237
            :||.||....|....|.:.:.          :||                    |..||.|:.|.
  Rat   133 LPWSTCPLDLNRTGFVQECQS----------SGT--------------------VSYFWYRQTLN 167

  Fly   238 ISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGA 302
            |:..|...|.|:|:|...|:..|...|.|:.:|::.||||:||||||||::|||.|:||:|||||
  Rat   168 ITSDISNTGTIQWKLFLCLVACWTTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLPGA 232

  Fly   303 LEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSS 367
            .||:.:...||...|.|..||:||.||||||..|..|..:|..|||:..||..|||:.:..|||.
  Rat   233 TEGLTYLFTPNMKILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNQPRNNCEKDAVTIALVNSM 297

  Fly   368 TSMFAGFVIFSVIGFMAHE---------------------------------------QQRPVA- 392
            ||::|...|||::||.|..                                       |...||
  Rat   298 TSLYASITIFSIMGFKASNDYGRCLDRNILSLINEFDFPELSISRDEYPSVLMYLNATQPERVAR 362

  Fly   393 ------------DVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITA 445
                        |.:||||||||:|:..|||.:||:.:||.|||.||..:||.|.|..|||.||.
  Rat   363 LPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHMPGASVWSVLFFGMLFTLGLSSMFGNMEGVITP 427

  Fly   446 IIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVS 508
            :.|  ..:|.|  .||....:||.:.:|..:....|.|.|..:|.||:|.| ..|:...|.|.|.
  Rat   428 LFD--MGILPKGVPKETMTGVVCFICFLSAICFTLQSGSYWLEIFDSFAAS-LNLIIFAFMEVVG 489

  Fly   509 ISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIV----------QWTPVKYL 563
            :...||:.||.|.|:.|.|..|:::|:..|.|.:|.:..|:|...||          .|.| :|.
  Rat   490 VIHVYGIKRFCDDIEWMTGRRPSLYWQVTWRVVSPMLLFGIFLSYIVLLAQSSPSYKAWNP-QYE 553

  Fly   564 DYS------YPWWAHAFGWFTALSSMLYIP-------LYMF-WLWKRT 597
            .:.      ||.|........:....|::|       |:.: ..||.|
  Rat   554 HFPSREEKLYPGWVQVTCVLLSFLPSLWVPGIALAQLLFQYRQRWKNT 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	222/619 (36%)
Slc6a18	NP_058859.2	SLC6sbd_B0AT3	16..591	CDD:212086	218/608 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810