Protein Alignment Gat and Slc6a4

DIOPT Version :9

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_037166.2
• Gene: Slc6a4 / 25553
• RGDID: 3714
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 605
• Identity: 248/605 - (40%)
• Similarity: 362/605 - (59%)
• Gaps: 55/605 - (9%)

  Fly    33 LQSSSPTTTDTSNKQQL----------------------------VKIEQLPDRGSWSSKMDFIL 69
            ||...|||.|.:...|:                            .:|.| .:|.:|..||||:|
  Rat    27 LQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQ-GERETWGKKMDFLL 90

  Fly    70 SVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVF-KIA 133
            ||:|.|:.|||:|||||:||:||||||:|||.|.....|||:|:|||||||....|.:.:: ||.
  Rat    91 SVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKIC 155

  Fly   134 PIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHC 198
            |||||||||..:::.::..||..|:|||::|...|:...:||.:|.|.|||.||.:.:.:.|: .
  Rat   156 PIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNI-T 219

  Fly   199 WDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQI--SHGIEEIGNIRWELAGTLLLVWI 261
            |                    :|..|.|.:||:.|..|||  |.|::::|.|.|:|...::|::.
  Rat   220 W--------------------TLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFT 264

  Fly   262 LCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDA 326
            :.||.||||||.:||||:.||.|||::|::|||||.|||||..|:.||:.||:.||..:.||:||
  Rat   265 VIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDA 329

  Fly   327 VTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPV 391
            ..|||||.|.|.|.|:|..|||||.||.|:|||:...||..||..:|||||:|:|:||..:...|
  Rat   330 AAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDV 394

  Fly   392 ADVAA-SGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLR 455
            ::||. :||.|.|:.|..|:..:|.|..::.:||.||:.:||||.|..:||.|||::||:|.:..
  Rat   395 SEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWA 459

  Fly   456 KRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYD 520
            ||:|.|:.||.....|..|..:|.||.|:..:|:.|| :|..:|.:...|.|::||.||:.:|..
  Rat   460 KRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYA-TGPAVLTVALIEAVAVSWFYGITQFCS 523

  Fly   521 GIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALSSMLY 585
            .:|:|:|:.|..:|:.||...:|...|.:....::....::...|:||.|:...|:...:||::.
  Rat   524 DVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVIC 588

  Fly   586 IPLYMFWLWKRTPGELSEKI 605
            ||.|:.:....|||.|.|:|
  Rat   589 IPTYIIYRLISTPGTLKERI 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	239/552 (43%)
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..60		7/32 (22%)
		5HT_transport_N	24..64	CDD:397524	7/36 (19%)
		SLC6sbd_SERT	79..615	CDD:271399	239/552 (43%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920