DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and Slc6a11

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_766478.1	Gene:	Slc6a11 / 243616	MGIID:	95630	Length:	627	Species:	Mus musculus

Alignment Length:	571	Identity:	308/571 - (53%)
Similarity:	405/571 - (70%)	Gaps:	24/571 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQM 121
            :||.|::|::|:|||.|..|||||||||||||||||||||::||::.....|||:||:|.||||.
Mouse    44 ERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQF 108

  Fly   122 LTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTV 185
            .:.||:..: ::.|:|:|||||..|:...:|||||:|||||:||.......::||.||.:.|||.
Mouse   109 TSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTE 173

  Fly   186 NCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQISHGIEEIGNIRW 250
            .|| ::::.|.           .....||..|.||     ||.||||||.|.||.|||.|||:||
Mouse   174 KCV-EFQKLNF-----------SNYSHVSLQNATS-----PVMEFWERRVLAISDGIEHIGNLRW 221

  Fly   251 ELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFS 315
            |||..||..|.:||||||||.|.||||||.||.|||::|.|||:||:|||||.||||||:.|:.|
Mouse   222 ELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLS 286

  Fly   316 KLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVI 380
            :|::.:||:||.|||||||.:.||.|.||||||.:.||.|:|.:::|.:||.||..|||.||||:
Mouse   287 RLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVL 351

  Fly   381 GFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITA 445
            ||||:||..|:|:||.|||||||:.||.||..:|.||:|:.|||.||:.:||||||..:|..:||
Mouse   352 GFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTA 416

  Fly   446 IIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVS 508
            ::|.:|::.|:  |:|:.|..:..:||.:||..:|:|||||||:.||||.||.|||::..||||.
Mouse   417 VVDMYPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVC 481

  Fly   509 ISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YSYPWWAH 572
            |.|.||.:||||.|:|||||.|....|:||.|.||.||.|:|.|.:|::.|:||.: |:||.|.:
Mouse   482 IGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGY 546

  Fly   573 AFGWFTALSSMLYIPLYMF-WLWKRTPGELSEKIRALVRIDEDVTRLREKM 622
            ..||..||||||.|||::| .||| |.|.|.||::.|.....|: ::|.|:
Mouse   547 GIGWLMALSSMLCIPLWIFIKLWK-TEGTLPEKLQKLTVPSADL-KMRGKL 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	305/557 (55%)
Slc6a11	NP_766478.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
Slc6a11	NP_766478.1	SLC6sbd_GAT3	44..585	CDD:212077	305/558 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820