DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and Slc6a7

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_006525992.1	Gene:	Slc6a7 / 240332	MGIID:	2147363	Length:	684	Species:	Mus musculus

Alignment Length:	584	Identity:	264/584 - (45%)
Similarity:	367/584 - (62%)	Gaps:	24/584 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QSSSPTTTD---TSNKQQLV--KIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGG 93
            |:..|.|.|   |.:.|..|  .::...|||:|:.|:||:||.:|..:||||||||||..|.|||
Mouse    55 QAGKPITPDLLMTPSDQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGG 119

  Fly    94 GAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVIL 158
            |||::||.:.|.:.|||:||:||:|||..::|.|.|:||:|:|||.|.|..::...:.:||.:|:
Mouse   120 GAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMII 184

  Fly   159 AWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLEL 223
            |:.:||.|.|:.:::||..|.|||||..|:.       |...|..||       |..||::|  .
Mouse   185 AYVLFYLFASLTSNLPWEHCGNWWNTELCLE-------HRGPKSGNG-------VLPLNLSS--T 233

  Fly   224 TDPVKEFWERRALQI--SHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPY 286
            ..|.:|:|.|..|.|  |.||...|.|||.|...|||.|::.:.||.||||.:||||||||.|||
Mouse   234 VSPSEEYWSRYVLHIQGSQGIGRPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPY 298

  Fly   287 VLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFT 351
            ::|.:|||||:|||||.:||:||:.|.|..|.:|:|||:|..|||:|.|:|.|.|:...|||.|.
Mouse   299 LILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFH 363

  Fly   352 NNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGS 416
            .|:|:|..||...|:.||:.|||.||||:|:|:.|...||..||.:||||||:|||.|:..||.|
Mouse   364 QNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLS 428

  Fly   417 PMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLRKRKEIFIAIVCALSYLVGLTCITQGG 481
            |.||.|||||||.:||||||..:|..:||:.||:|..||.:|.:|..::|...||:||...|.||
Mouse   429 PFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGG 493

  Fly   482 MYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAIC 546
            ||...:||.|:.| |.|:.::...|::::..||:.||...|..|:|:.|.::::.||...:||..
Mouse   494 MYWLVLLDDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATL 557

  Fly   547 LGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVR 610
            |.:..::||::.|.:|..|.:|.||...|....|.|.|.||..|.....|..|.|.|:::...|
Mouse   558 LALLVYSIVKYQPSEYGSYRFPAWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASR 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	256/555 (46%)
Slc6a7	XP_006525992.1	SLC5-6-like_sbd	84..628	CDD:382020	256/555 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820