DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and Slc6a18

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001035782.1	Gene:	Slc6a18 / 22598	MGIID:	1336892	Length:	615	Species:	Mus musculus

Alignment Length:	615	Identity:	222/615 - (36%)
Similarity:	310/615 - (50%)	Gaps:	107/615 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAG 108
            |....||.||.  :|..|.:|:.::||.:|.|:||||:|||||||..:|||||::||.|.|...|
Mouse     5 SGMDPLVDIED--ERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFEG 67

  Fly   109 IPMFFMELALGQMLTIGGLGVFK-IAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRAD 172
            ||:|::|||:||.|..|.:||:| |:|...|:|.....:|..:::||..:|.|.:::|..|.:..
Mouse    68 IPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTVLLWVLWFFLNSFQHP 132

  Fly   173 VPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQ 237
            :||.||....|....|.:.:.          :||                    |..||.|:.|.
Mouse   133 LPWSTCPLDLNRTGFVQECQS----------SGT--------------------VSYFWYRQTLN 167

  Fly   238 ISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGA 302
            |:..|...|.|:|:|...|:..|...|.|:.:|::.||||:||||||||::|||.|:||:|||||
Mouse   168 ITSDISNTGTIQWKLFLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLPGA 232

  Fly   303 LEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSS 367
            .||:.:...||...|.|..||:||.||||||..|..|..:|..|||...||..|||:|:..|||.
Mouse   233 TEGLIYLFTPNMKTLQNPRVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALVNSM 297

  Fly   368 TSMFAGFVIFSVIGFMAHEQ--------------------------------------------Q 388
            ||::|...||||:||.|...                                            |
Mouse   298 TSLYASIAIFSVMGFKASNDYGRCLDRNILSLINEFDLPELSISRDEYPSVLMYLNATQTARVAQ 362

  Fly   389 RPV--------ADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITA 445
            .|:        .|.:||||||||:|:..|||.:||:.:||.|||.||..:||.|.|..|||.||.
Mouse   363 LPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHMPGASVWSVLFFGMLFTLGLSSMFGNMEGVITP 427

  Fly   446 IIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVS 508
            ::|  ..:|.|  .||:...::|...:|..:....|.|.|..:|.||:|.| ..|:...|.|.|.
Mouse   428 LLD--MGILPKGIPKEVMTGVICFACFLSAICFTLQSGGYWLEIFDSFAAS-LNLIIFAFMEVVG 489

  Fly   509 ISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIV----------QWTPVKYL 563
            :...||:.||.|.|:.|.|..|.::|:..|.|.:|.:..|:|...||          .|.| :|.
Mouse   490 VIHIYGMKRFCDDIEWMTGRRPGLYWQVTWRVVSPMLLFGIFLSYIVLLIQTPPSYKAWNP-QYE 553

  Fly   564 DYS------YPWWAHAFGWFTALSSMLYIP 587
            .:.      ||.|........:....|::|
Mouse   554 HFPSREEKFYPGWVQVTCVLLSFLPSLWVP 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	217/601 (36%)
Slc6a18	NP_001035782.1	SLC6sbd_B0AT3	16..591	CDD:212086	217/602 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810