Protein Alignment Gat and Slc6a6

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_033346.2
• Gene: Slc6a6 / 21366
• MGIID: 98488
• Length: 621
• Species: Mus musculus
• Alignment Length: 558
• Identity: 310/558 - (55%)
• Similarity: 399/558 - (71%)
• Gaps: 20/558 - (3%)

  Fly    56 PDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQ 120
            |.|..||||:||:|||.|..:||||||||||||||||||||::||.|.||.:|:|:||:|:.:||
Mouse    39 PQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEVIIGQ 103

  Fly   121 MLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNT 184
            ..:.||:..: ||.|:|.|||||:.|:...:|||||||||||.:|.|.|.:.|:||..||:.|||
Mouse   104 YTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFHSFQKDLPWAHCNHSWNT 168

  Fly   185 VNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQISHGIEEIGNIR 249
            ..|:....|:|...|           .|:|..|.||     ||.|||||..|.:|.||:..|:::
Mouse   169 PQCMEDTLRRNESHW-----------VSLSTANFTS-----PVIEFWERNVLSLSSGIDNPGSLK 217

  Fly   250 WELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNF 314
            |:||..|||||::|:|||||||:.|||||||||.||:.:|.:|||||:|||||.||||||:.|:.
Mouse   218 WDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDI 282

  Fly   315 SKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSV 379
            |:|.:.:|||||.|||||||.:.||.:.:||||||:..|.|:|.:::..:||.||..:||.|||:
Mouse   283 SRLGDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSI 347

  Fly   380 IGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFIT 444
            :||||.||...:||||.|||||||:.||.||..:|....||.|||.||||:||||||..:||.||
Mouse   348 LGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQIT 412

  Fly   445 AIIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECV 507
            :::|.:|..|||  |:||||||:|::|||:|||.:|:||||:||:.|.||.||.||||:.||||.
Mouse   413 SLVDLYPSFLRKGYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECF 477

  Fly   508 SISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YSYPWWA 571
            .|:|.||.|..||||:|||||.|..|.|:.|.|.|||:|:|.|.|::|::.|:.|.. |.||.||
Mouse   478 VIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFVFSLVKYVPLTYNKVYRYPDWA 542

  Fly   572 HAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALV 609
            ...||..||||||.|||.:..|..||.|.|..:|:.|:
Mouse   543 IGLGWGLALSSMLCIPLVIVILLCRTEGPLRVRIKYLI 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	309/556 (56%)
Slc6a6	NP_033346.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		1/2 (50%)
		SLC5-6-like_sbd	41..582	CDD:444915	309/556 (56%)