Protein Alignment Gat and Slc6a2

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_033235.3
• Gene: Slc6a2 / 20538
• MGIID: 1270850
• Length: 617
• Species: Mus musculus
• Alignment Length: 609
• Identity: 257/609 - (42%)
• Similarity: 371/609 - (60%)
• Gaps: 49/609 - (8%)

  Fly    11 GGGD--------VCKHESIEMSKELGHTTSLQSSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDF 67
            ||.|        .||...:.:.||......|.:|..:...              .|.:|..|:||
Mouse    15 GGADPLPEQPLRPCKTADLLVVKERNGVQCLLASQDSDAQ--------------PRETWGKKIDF 65

  Fly    68 ILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFKI 132
            :|||||.|:.|.|||||||||||||||||::||.:.|.:||:|:|:|||||||....|...|:||
Mouse    66 LLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKI 130

  Fly   133 APIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLH 197
            .|.|||:|||..:::.::..||.||:||:::|.|.|...::||..|.:.||:.||
Mouse   131 CPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHSWNSPNC---------- 185

  Fly   198 CWDKIINGTTQKVCSVSAL----NITSLELTDPVKEFWERRALQI--SHGIEEIGNIRWELAGTL 256
                    |..|:.:.|.|    ..:..:.| |..||:||..|.:  |.||.:||..:|:|...|
Mouse   186 --------TDPKLLNASVLGDHTKYSKYKFT-PAAEFYERGVLHLHESSGIHDIGLPQWQLLLCL 241

  Fly   257 LLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSE 321
            ::|.::.||.:|||||.:||||:.||..||.:|.:|||.|:|||||..||..|:..:|.:|..:.
Mouse   242 MVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEAT 306

  Fly   322 VWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHE 386
            |||||.||||||.|.|.|.|:|..|||||.||.|:|||:..|:|..||..:||.|||::|:||||
Mouse   307 VWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHE 371

  Fly   387 QQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWP 451
            .:..:.|||..|.||.|::||.|:..|.||..|:.|||.|||.:||||....||..||.:.|::
Mouse   372 HKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDF- 435

  Fly   452 QLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVD 516
            |:|::.:::|..:|...::|:.|.|||:||:|:..:||::| :|..:|:.:..|.:.:||.||||
Mouse   436 QVLKRHRKLFTCVVTISTFLLALFCITKGGIYVLTLLDTFA-AGTSILFAVLMEAIGVSWFYGVD 499

  Fly   517 RFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALS 581
            ||.:.|:.|:|:.|.::|:.||...:||..|.|...:|:.:.|:.|.||:||.||:..||..|||
Mouse   500 RFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYTYPPWANWVGWGIALS 564

  Fly   582 SMLYIPLYMFWLWKRTPGELSEKI 605
            ||:.:|.|:.:.:....|.|.|::
Mouse   565 SMILVPAYVIYKFLSIRGSLWERV 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	248/554 (45%)
Slc6a2	NP_033235.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		3/5 (60%)
		SLC5-6-like_sbd	56..615	CDD:444915	248/554 (45%)