DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and snf-11

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_505873.2	Gene:	snf-11 / 191770	WormBaseID:	WBGene00004910	Length:	610	Species:	Caenorhabditis elegans

Alignment Length:	598	Identity:	337/598 - (56%)
Similarity:	439/598 - (73%)	Gaps:	39/598 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFF 113
            :|:...:.:|..|||..|||:|.:|.|||||||||||||||:||||||::||.|:|...|.|:|.
Worm     1 MVEATSVAEREQWSSWADFIMSCIGYAIGLGNVWRFPYLCYQNGGGAFLIPYCISLVFCGAPLFI 65

  Fly   114 MELALGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSM-RADVPWRT 177
            :|.:.||::::||||:|||.|||||:|.|||||:.|:|:||||:|:||..|.:.|. .:||||:.
Worm    66 LETSWGQLMSVGGLGMFKICPIFKGVGIAAAVMAFWLNIYYIVVLSWAATYLYNSFTMSDVPWKN 130

  Fly   178 CNNWWNTVNCVSQYER--------------------KNLHCWDK------IINGTTQKVCSVSAL 216
            |::.|||.||.|:|.:                    .::|.:.|      .:|.|   |||.:.|
Worm   131 CDHAWNTPNCRSEYVKIPCDSNRTIAEFFNVKVLTHDHIHEYKKQFFVGEKMNWT---VCSAADL 192

  Fly   217 NITSLELTDPVKEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFT 281
            ::.|     ||||||..|.|.||.|:|..|.|||:||..||||||:||.||:|||||||||||.|
Worm   193 SVVS-----PVKEFWNHRVLGISSGLENPGGIRWDLALFLLLVWIICYLCIFKGVKWTGKVVYIT 252

  Fly   282 ALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGS 346
            |.|||::|..||:||:||.||..|::||:.|:||||..|:||:|||||:|||||||||.||||||
Worm   253 ASFPYMMLFCLLIRGLTLEGAGVGLEFYLKPDFSKLLESKVWVDAVTQVFFSYGLGLGALVALGS 317

  Fly   347 YNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVL 411
            ||||.|||||.||.||.|||.||:||||||||.|||||.:|::.||:||.:||||.||.|||.:|
Worm   318 YNKFNNNVYKQALTVCFVNSGTSVFAGFVIFSFIGFMATQQEKSVAEVAQAGPGLLFLAYPSGIL 382

  Fly   412 QLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLRKR--KEIFIAIVCALSYLVGL 474
            |||.:..||||||.|:|.:|:||||||||||.||||||:||:.||:  :|||:.::|.:|||:||
Worm   383 QLPYTQFWSCLFFLMVLFLGVDSQFCTMEGFFTAIIDEFPQIRRKKYGREIFVGVICVISYLIGL 447

  Fly   475 TCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWC 539
            |.:|:||.|:||:.|.||.||:.||||:||||::|||..|:||:|:.:|.||||||:.||||||.
Worm   448 TTVTEGGFYVFQLFDFYAASGWALLWLLFFECIAISWSLGIDRWYEHMKSMIGYYPSAWWKFCWV 512

  Fly   540 VTTPAICLGVFFFNIVQWTPVKY--LDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELS 602
            ..||::|.||..|.::::.|::.  .:|.||.|.|.||||.:|||||.||.|..|:|.:|||.:.
Worm   513 FATPSVCFGVLLFGLIKYQPLRIDAYNYDYPVWGHIFGWFLSLSSMLCIPGYAIWIWFKTPGTVQ 577

  Fly   603 EKIRALVRIDEDV 615
            |||:.|.|.|.::
Worm   578 EKIKLLCRPDIEI 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	334/583 (57%)
snf-11	NP_505873.2	SLC6sbd-TauT-like	10..586	CDD:271387	334/583 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158719
Domainoid	1	1.000	704	1.000	Domainoid score	I51
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2290
Inparanoid	1	1.050	726	1.000	Inparanoid score	I320
Isobase	1	0.950	-	0	Normalized mean entropy	S2610
OMA	1	1.010	-	-		QHG49243
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	1	1.000	-	-		oto17749
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3258
SonicParanoid	1	1.000	-	-		X3352
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750