Protein Alignment Gat and Slc6a4

DIOPT Version :9

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_034614.2
• Gene: Slc6a4 / 15567
• MGIID: 96285
• Length: 630
• Species: Mus musculus
• Alignment Length: 603
• Identity: 251/603 - (41%)
• Similarity: 367/603 - (60%)
• Gaps: 33/603 - (5%)

  Fly     7 SDGDGGGDVCKHESIEMSKELGHTTSLQSSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSV 71
            :|..|.|.:....|...|      ||....:|.:|..:....:.:|.| .:|.:|..||||:|||
Mouse    35 ADKAGPGQISNGYSAVPS------TSAGDEAPHSTPAATTTLVAEIHQ-GERETWGKKMDFLLSV 92

  Fly    72 VGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVF-KIAPI 135
            :|.|:.|||:|||||:||:||||||:|||.|.....|||:|:|||||||....|.:.:: ||.||
Mouse    93 IGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPI 157

  Fly   136 FKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWD 200
            |||||||..:::.::..||..|:|||::|...|....:||.:|.|.|||.||.:.:.:.|: .|
Mouse   158 FKGIGYAICIIAFYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNI-TW- 220

  Fly   201 KIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQI--SHGIEEIGNIRWELAGTLLLVWILC 263
                               :|..|.|.:||:.|..|||  |.|::::|.|.|:||..::|::.:.
Mouse   221 -------------------TLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLALCIMLIFTII 266

  Fly   264 YFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVT 328
            ||.||||||.:||||:.||.|||::|::|||||.|||||..|:.||:.||:.||..:.||:||..
Mouse   267 YFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAA 331

  Fly   329 QIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVAD 393
            |||||.|.|.|.|:|..|||||.||.|:|||:...||..||..:|||||:|:|:||..:...|::
Mouse   332 QIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSE 396

  Fly   394 VAA-SGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLRKR 457
            ||. :||.|.|:.|..|:..:|.|..::.:||.||:.:||||.|..:||.|||::||:|.:..||
Mouse   397 VAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKR 461

  Fly   458 KEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGI 522
            :|.|:.||.....|..|..:|.||.|:..:|:.|| :|..:|.:...|.|.:||.||:.:|...:
Mouse   462 REWFVLIVVITCILGSLLTLTSGGAYVVTLLEEYA-TGPAVLTVALIEAVVVSWFYGITQFCSDV 525

  Fly   523 KDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALSSMLYIP 587
            |:|:|:.|..:|:.||...:|...|.:....::....::...|:||.|:...|:....||::.||
Mouse   526 KEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSVICIP 590

  Fly   588 LYMFWLWKRTPGELSEKI 605
            :|:.:....|||.|.|:|
Mouse   591 IYIIYRLISTPGTLKERI 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	240/552 (43%)
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		8/33 (24%)
		5HT_transport_N	24..64	CDD:281488	8/34 (24%)
		SLC6sbd_SERT	79..615	CDD:271399	240/552 (43%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820