Protein Alignment Gat and Slc6a9

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001342104.1
• Gene: Slc6a9 / 14664
• MGIID: 95760
• Length: 652
• Species: Mus musculus
• Alignment Length: 613
• Identity: 258/613 - (42%)
• Similarity: 385/613 - (62%)
• Gaps: 26/613 - (4%)

  Fly    12 GGD---VCKHESIEMSKELGHTTSLQSSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVG 73
            |||   ...|..:..::....|.|.:.:....::.:.|.|.:      .||:|.::::|:|:.||
Mouse     3 GGDTRAASAHPGMASAQGPVATPSPEQNGAVPSEATKKDQNL------TRGNWGNQIEFVLTSVG 61

  Fly    74 LAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFKIAPIFKG 138
            .|:|||||||||||||:||||||:.||.|.|...|||:|||||:.||..:.|.|||::|:|:|||
Mouse    62 YAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG 126

  Fly   139 IGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKII 203
            :||...|:|.::.:||.|::..|.:|||.||...:||..|||.|||.:|....:..||      .
Mouse   127 VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNL------T 185

  Fly   204 NGTTQKVCS--VSALNITSLELTDPVKEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFC 266
            ||:.....|  :|.|...:|:.|.|.:|:|....|::|..|...|.:|..|.|.|.:.|::.:.|
Mouse   186 NGSRPAALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLC 250

  Fly   267 IWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIF 331
            :.:|||.:||||||||.||||:||||.|||:||.||..||.:|:.|.:.|:..::||.||.:|||
Mouse   251 LIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIF 315

  Fly   332 FSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAA 396
            :|.|...|.|:.:.|||||.||.|:|::|:...|.:||::|||||||::||||:.....|:.||.
Mouse   316 YSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVAD 380

  Fly   397 SGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIID----EWPQLLRKR 457
            .||||||:.||.|:..||.||:||.||||||:|:||.:|||.:|..:|||:|    ||  :|:|:
Mouse   381 HGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEW--ILQKK 443

  Fly   458 KEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGI 522
            ..:.:.:..| .:|:|:...:|.|:|...::|:||.| |.|:.:....||||.:.||...::..|
Mouse   444 TYVTLGVAVA-GFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVSIMYIYGHRNYFQDI 506

  Fly   523 KDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALSSMLYIP 587
            :.|:|:.|.::::.||...:|||...:..|.::|:.|:.|..|.||.||.|.|:..||||::.||
Mouse   507 QMMLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIP 571

  Fly   588 LYMFWLWKRTPGE-LSEKIRALVRIDED 614
            ||..:...||.|: |.::::...:...|
Mouse   572 LYALFQLCRTDGDTLLQRLKNATKPSRD 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	249/559 (45%)
Slc6a9	NP_001342104.1	SLC6sbd_GlyT1	30..613	CDD:212067	252/586 (43%)