Protein Alignment Gat and Slc6a12

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_598422.2
• Gene: Slc6a12 / 14411
• MGIID: 95628
• Length: 628
• Species: Mus musculus
• Alignment Length: 565
• Identity: 298/565 - (52%)
• Similarity: 397/565 - (70%)
• Gaps: 24/565 - (4%)

  Fly    53 EQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELA 117
            :|:.|||.|::||:|:|||.|..|||||||||||||||||||||.:||.|..|..|||:||:|:|
Mouse    45 DQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVA 109

  Fly   118 LGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNW 181
            |||..:.|.:..: ||.|:.:|||.|:.|:..::|:|||:|||||:||.|.|...::||.||.|.
Mouse   110 LGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNS 174

  Fly   182 WNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLE-LTDPVKEFWERRALQISHGIEEI 245
            |||.:||.            .:|.:       ||..::|.| .|.||.||||||.|.|:.||.::
Mouse   175 WNTEHCVD------------FLNHS-------SARGVSSSENFTSPVMEFWERRVLGITSGIHDL 220

  Fly   246 GNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYI 310
            |::|||||..|||.||:||||||||||.|||||||||.|||::|.|||:||:|||||.:||.||:
Mouse   221 GSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYL 285

  Fly   311 IPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFV 375
            .|:..:|.:.:||:||.||||||:.:..|.|.|||||||:.||.|:|::.:|.:||:||..||||
Mouse   286 KPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFV 350

  Fly   376 IFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTME 440
            :||::|||:.||..|:::||.|||||||:.:|.||..:|.|.:||||||.|||.:||||||..||
Mouse   351 VFSILGFMSQEQGIPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCME 415

  Fly   441 GFITAIIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIF 503
            ..:||.:|.:||.|||  |:|:.|..:..|.||:||..:|:|||||||:.|.||.||.|||:|..
Mouse   416 CLVTASMDMFPQQLRKSGRRELLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSL 480

  Fly   504 FECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YSY 567
            ||.:.|.|.||.|||||.::|||||.|....|..|...||.:||..|||::.::||:||.: |.|
Mouse   481 FEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMY 545

  Fly   568 PWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVRID 612
            |.|.::.||..|.|||..:||::...:.:|.|...:::|.|:..|
Mouse   546 PSWGYSIGWLLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITPD 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	295/557 (53%)
Slc6a12	NP_598422.2	SLC5-6-like_sbd	49..589	CDD:444915	296/558 (53%)