Protein Alignment Gat and Slc6a3

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_034150.1
• Gene: Slc6a3 / 13162
• MGIID: 94862
• Length: 619
• Species: Mus musculus
• Alignment Length: 572
• Identity: 252/572 - (44%)
• Similarity: 365/572 - (63%)
• Gaps: 25/572 - (4%)

  Fly    49 LVKIEQLP----DRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGI 109
            |:...|.|    :|.:||.|:||:|||:|.|:.|.|||||||||||||||||::||::.:.:||:
Mouse    47 LINPPQTPVEVQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGM 111

  Fly   110 PMFFMELALGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVP 174
            |:|:|||||||....|..||:||.|:.||:|:...::|.::..:|.||:|||:.|||.|...|:|
Mouse   112 PLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLP 176

  Fly   175 WRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQI- 238
            |..|||.||:.||...:...                 |...|.:.....|.|..|::||..|.:
Mouse   177 WIHCNNTWNSPNCSDAHSSN-----------------SSDGLGLNDTFGTTPAAEYFERGVLHLH 224

  Fly   239 -SHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGA 302
             |.||:::|..||:|...|:||.:|.||.:|||||.:||||:.||..|||:||.||:||:|||||
Mouse   225 QSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGA 289

  Fly   303 LEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSS 367
            ::||:.|:..:|.:|..:.|||||.||:.||.|:|.|.|:|..||||||||.|:||:|..::||.
Mouse   290 MDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSL 354

  Fly   368 TSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGL 432
            ||..:|||:||.:|:||.:...|:.|||..||||.|::||.|:..||.|..|:.:||.|||.:|:
Mouse   355 TSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGI 419

  Fly   433 DSQFCTMEGFITAIIDEWPQLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFC 497
            ||....||..||.::||: |||.:.:|:|...:...::|:.|.|:|.||:|:|.:||.:| :|..
Mouse   420 DSAMGGMESVITGLVDEF-QLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFA-AGTS 482

  Fly   498 LLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKY 562
            :|:.:..|.:.::|.|||.:|.|.||.|.|..|.::|:.||.:.:|...|.|...:||.:.|..|
Mouse   483 ILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHY 547

  Fly   563 LDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVRIDED 614
            ..|.:|.||:|.||..|.|||..:|:|..:.:...||...||:...:..::|
Mouse   548 GAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKD 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	248/554 (45%)
Slc6a3	NP_034150.1	SLC5-6-like_sbd	60..613	CDD:444915	249/559 (45%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		10/28 (36%)