DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and SLC6A14

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_009162.1	Gene:	SLC6A14 / 11254	HGNCID:	11047	Length:	642	Species:	Homo sapiens

Alignment Length:	551	Identity:	243/551 - (44%)
Similarity:	354/551 - (64%)	Gaps:	25/551 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQM 121
            |||:||.|.|::||::|.|:|||||||||||.|.||||||::||.|.|.|||:|:||:|.:|||.
Human    35 DRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQF 99

  Fly   122 LTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVN 186
            .::|.:.|::|.|:|:|:|....::|.::.:||.||:|::::|.|.|.::::||:.|:: |:..|
Human   100 ASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSS-WSDKN 163

  Fly   187 CVSQYERKNL--HCWDKIINGTTQKVCS-----VSALNITSLELTD-------PVKEFWERRALQ 237
            |    .|..:  ||....:|...|::..     |...|.|.:..::       |.:::|.:.|||
Human   164 C----SRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQ 224

  Fly   238 ISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGA 302
            .|.|:.|.|.|.|.||..|||.|::....::||:|.:|||||||||||||:|.||||||.||.||
Human   225 RSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGA 289

  Fly   303 LEGIKFYI--IPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVN 365
            .:||.:||  ..||:||..:|||.||.||||:|..:..|.||||.|||||.||.:.||::||..|
Human   290 SKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTN 354

  Fly   366 SSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLI 430
            ..||:||||.|||::|.|||...:.|:.|..||..|||:.||.|:.||||.|.||.|||||||.:
Human   355 CLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTL 419

  Fly   431 GLDSQFCTMEGFITAIIDEWPQLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSG 495
            ||||||.::|...|.|.|.:|::::|.:.......|.:.:|:||.|:||.|:|...::|.:. :|
Human   420 GLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFC-AG 483

  Fly   496 FCLLWLIFFECVSISWCYGVDRFYDGIKDMIG---YYPTVWWKFCWCVTTPAICLGVFFFNIVQW 557
            :.:|.....|.|.|.|.||.:||.:..:.|||   :...:||:.||.|.||.:.:.:|.:::||:
Human   484 WGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQF 548

  Fly   558 TPVKYLDYSYPWWAHAFGWFTALSSMLYIPL 588
            ....|....||.|..|.||...:..:::||:
Human   549 HRPNYGAIPYPDWGVALGWCMIVFCIIWIPI 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	242/550 (44%)
SLC6A14	NP_009162.1	SLC6sbd_ATB0	36..641	CDD:271391	242/550 (44%)
SLC6A14	NP_009162.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..642
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820