DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and Slc6a15

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001239259.1	Gene:	Slc6a15 / 103098	MGIID:	2143484	Length:	729	Species:	Mus musculus

Alignment Length:	701	Identity:	215/701 - (30%)
Similarity:	345/701 - (49%)	Gaps:	148/701 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 IEMSKELGHTTSLQSSSPTTTDTSNKQQL-VKIEQLPD------------RGSWSSKMDFILSVV 72
            ||..|:      |.|:..:..:.|.|.:| |.:::..|            |.:|:||:.:||:.|
Mouse    17 IESVKD------LLSNEDSVEEVSKKSELIVDVQEEKDTDAEDGSEADDERPAWNSKLQYILAQV 75

  Fly    73 GLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFK-IAPIF 136
            |.::||||||||||||.||||||::|||:|.|.:.|||:||:||::||.:..|.:||:. |:|..
Mouse    76 GFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYISPKL 140

  Fly   137 KGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDK 201
            .|||:|:.|:..::.:||.||:.|.:|||..|.:..:||..|....|..:...:.|
Mouse   141 GGIGFASCVVCYFVALYYNVIIGWTLFYFSQSFQQPLPWDQCPLVKNASHTYVEPE--------- 196

  Fly   202 IINGTTQKVCSVSALNITSLELTDPVKEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFC 266
                     |          |.:.....:|.|.||.|:..|.:.|.:.|::...||:.|::....
Mouse   197 ---------C----------EQSSATTYYWYREALDITSSISDSGGLNWKMTVCLLVAWVMVCLA 242

  Fly   267 IWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIF 331
            :.||::.:||::||::|||||:|...|:|.:.|.|:::||:....|....:...:||.:|.||:|
Mouse   243 MIKGIQSSGKIMYFSSLFPYVVLICFLIRSLLLNGSIDGIRHMFTPKLEMMLEPKVWREAATQVF 307

  Fly   332 FSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAH----------- 385
            |:.|||.|.::|..||||..||.:.||::|..:|..||:.|..|:|:|:||.|:
Mouse   308 FALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANIVNEKCISQNS 372

  Fly   386 ----------------------------EQQRPVADV-------------------------AAS 397
                                        |..|.|.|:                         |..
Mouse   373 EMILKLLKMGNISWDVIPHHINLSAVTVEDYRLVYDIIQKVKEEEFAVLHLNACQIEDELNKAVQ 437

  Fly   398 GPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLRKRKEIFI 462
            |.||||:.:..|:...|.||.||.:||.||:.:||.|.|.|:||.||.|:|.:    :.||||..
Mouse   438 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMFGTIEGIITPIVDTF----KVRKEILT 498

  Fly   463 AIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIG 527
            .|.|.|::.:||..:.:.|.|...:.|.|:.: ..||.::..|.:::|:.||:|:|.:.:.||:|
Mouse   499 VICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVSFVYGIDKFIEDLTDMLG 562

  Fly   528 YYPTVWWKFCWCVTTPAICLGVFFFNIVQ----------WTPVKYLD--YSYPWWAHAFGWFTAL 580
            :.|:.::.:.|...:|.:.|.:...:||.          |...|..:  .|||.|.....:...:
Mouse   563 FAPSKYYYYMWKYISPLMLLTLLIASIVNMGLSPPGYNAWIKEKASEEFLSYPMWGMVVCFSLMV 627

  Fly   581 SSMLYIPLYMFWLWKRTPGELSEKIRALVRIDE------DVTRLREKMLRE 625
            .::|.:|:...             ||....||:      .||..|.::|:|
Mouse   628 LAILPVPVVFI-------------IRRCNLIDDSSGNLASVTYKRGRVLKE 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	198/629 (31%)
Slc6a15	NP_001239259.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..61		1/18 (6%)
Slc6a15	NP_001239259.1	SLC6sbd_SBAT1	61..640	CDD:212091	196/624 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820