Protein Alignment Gat and slc6a8

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_002935539.1
• Gene: slc6a8 / 100489909
• XenbaseID: XB-GENE-986840
• Length: 644
• Species: Xenopus tropicalis
• Alignment Length: 564
• Identity: 297/564 - (52%)
• Similarity: 399/564 - (70%)
• Gaps: 16/564 - (2%)

  Fly    53 EQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELA 117
            |.:|:|.:|:|:||||:|.||.|:||||||||||||||||||.|::|||:...|.|||:||:|:|
 Frog    53 EGIPERDTWTSQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYILIAILGGIPIFFLEIA 117

  Fly   118 LGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWW 182
            |||.:..|.:.|:.|||:|:|||:|:.|:..:.|.|||:||.|.|:|...|..|.:||..|||.|
 Frog   118 LGQFMKAGSIAVWNIAPLFQGIGFASVVIVFFCNTYYILILTWGVYYLVKSFSAVLPWSHCNNTW 182

  Fly   183 NTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTD---PVKEFWERRALQISHGIEE 244
            |:.:||..:.:::  |    .|||......    |:|..||.|   |:.||||::.|::|.|:::
 Frog   183 NSPDCVDIFRQED--C----TNGTANSTFG----NLTCNELADKVSPITEFWEKKVLRLSSGLDD 237

  Fly   245 IGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFY 309
            ||:|.|||...|:..|:|.|||:|||||.|||:|||||.||||:|.||||||..||||.|||.:|
 Frog   238 IGSINWELLLCLIGCWLLVYFCVWKGVKSTGKIVYFTATFPYVVLLILLVRGAMLPGATEGIIYY 302

  Fly   310 IIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGF 374
            :.|::|||..::|||||.|||||||.:|||.|.||||||:|.|:.||||.|:..:||.||.||||
 Frog   303 LKPDWSKLGTAQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNDCYKDAFILAVINSGTSFFAGF 367

  Fly   375 VIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTM 439
            |:||::||||:||...::.||.|||||||:.||.||..:|.:|:||.||||||||:||||||..:
 Frog   368 VVFSILGFMANEQGVDISKVAESGPGLAFIAYPRAVSLMPVAPLWSALFFFMLLLLGLDSQFVGV 432

  Fly   440 EGFITAIIDEWP--QLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLI 502
            ||.||||:|..|  ...|.::||.:||.||:.:|:.|:.:|:||||:||:.|.|:.||..|||..
 Frog   433 EGLITAILDLLPARYYFRFQREIAVAICCAIMFLIDLSMLTEGGMYVFQLFDYYSASGMTLLWQT 497

  Fly   503 FFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YS 566
            |::||.::|.||.|||.|.|..||||.|..|.|:||...||.:|:.:|.||::.:.|:.|.: |:
 Frog   498 FWQCVVVAWVYGADRFMDDIARMIGYRPFPWMKWCWSFVTPFVCMAIFLFNLINYKPLTYNNSYT 562

  Fly   567 YPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVR 610
            ||||..|.||..||||||.:|:...:......|.|.|:.:.|.:
 Frog   563 YPWWGEAIGWGFALSSMLCVPVTFLYKITCAKGSLRERWQHLTK 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	295/559 (53%)
slc6a8	XP_002935539.1	SLC5-6-like_sbd	58..644	CDD:444915	295/559 (53%)