DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and slc6a14

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001313379.1	Gene:	slc6a14 / 100150665	ZFINID:	ZDB-GENE-130411-2	Length:	614	Species:	Danio rerio

Alignment Length:	583	Identity:	239/583 - (40%)
Similarity:	367/583 - (62%)	Gaps:	37/583 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DTSNK-QQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLF 105
            |.|:| :.:|:.::..|||:||||.:::||::|.|:|||||||||||.||:|||||::||.|.|.
Zfish    25 DKSDKAEHVVQNDENSDRGNWSSKREYMLSMIGYAVGLGNVWRFPYLAYKHGGGAFLIPYTIMLA 89

  Fly   106 LAGIPMFFMELALGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMR 170
            ::|:|:||||.:.||..:.|.:.|:|..||.:|:|....::|.::.:||.||:|::::|.|.|.:
Zfish    90 VSGLPLFFMESSFGQFCSQGPINVWKAVPILQGVGITMMLVSTFVAIYYNVIIAYSIYYLFASFQ 154

  Fly   171 ADVPW--RTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDP--VKEFW 231
            ..:||  :.||                          ||....|.:|:|::..:::..  .:::|
Zfish   155 DPLPWSIKNCN--------------------------TTASNISTAAVNVSCGQISGQSLSEKYW 193

  Fly   232 ERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRG 296
            :..|||.|..::|.|.:.|.||..|||.|||....::||:|.:||||||||.|||::|.|||:||
Zfish   194 DEVALQRSSSMDETGPVVWHLALCLLLSWILVGAALFKGIKSSGKVVYFTATFPYIVLLILLIRG 258

  Fly   297 ITLPGALEGIKFYI--IPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDAL 359
            .||.||.:||:|||  ..|.:||..:|||.||.||||||..:..|.|:||.|||||.||.|:|::
Zfish   259 ATLEGAKDGIEFYIGSQSNLTKLAEAEVWKDAATQIFFSLSIAWGGLMALSSYNKFYNNCYQDSI 323

  Fly   360 IVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFF 424
            :||..|..||:||||.||||:|.|||..||||::||.:|..|||:.||.|:.:||.||:||.|||
Zfish   324 VVCVTNCGTSIFAGFAIFSVLGHMAHVYQRPVSEVADAGFALAFIAYPDALSKLPISPLWSILFF 388

  Fly   425 FMLLLIGLDSQFCTMEGFITAIIDEWPQLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILD 489
            |||:.:||||||..:|...|.::|.:|::|:.::.:....||.:.:|:||.|:|:.|:|...::|
Zfish   389 FMLITLGLDSQFAGIEVISTCLLDAYPEVLKSKRGLVTTAVCIILFLLGLPCVTRAGIYWVNLID 453

  Fly   490 SYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPT---VWWKFCWCVTTPAICLGVFF 551
            ::: :|:.||.....|.:.:...||.:||...|:.|||...:   :||:.||...||.:...:..
Zfish   454 TFS-AGWILLVAGLLEVLGLCILYGGNRFIKDIEMMIGTKSSLFWLWWRACWFFITPVVLSIILI 517

  Fly   552 FNIVQWTPVKYLDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVRIDED 614
            :::..:|...|...:||.|..:.||.....|:::||:...|...:..|.|.::|::.....||
Zfish   518 WSLYTFTSPTYSSVAYPDWGISLGWCITAFSLMWIPIVAVWKVCKARGGLWQRIKSACSPTED 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	232/561 (41%)
slc6a14	NP_001313379.1	SLC6sbd_ATB0	42..612	CDD:271391	234/566 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820