DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and slc6a11b

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_017213744.2	Gene:	slc6a11b / 100150472	ZFINID:	ZDB-GENE-121116-2	Length:	617	Species:	Danio rerio

Alignment Length:	591	Identity:	303/591 - (51%)
Similarity:	405/591 - (68%)	Gaps:	33/591 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QSSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFIL 98
            :|::|:.. .||.:::|.     :||.|::|::|:|||.|..|||||||||||||||||||||.:
Zfish    21 ESANPSAV-RSNDKKVVN-----ERGQWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFV 79

  Fly    99 PYIITLFLAGIPMFFMELALGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAV 162
            ||:|.....|||:||:|.||||..:.||:..: |:.|:|:|||||..|:...:||||:||||||:
Zfish    80 PYVIFFVCCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYVVILAWAI 144

  Fly   163 FYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPV 227
            ||.|.....::||.:|.::|||.|||.             .|       :.|..|.|:...|.||
Zfish   145 FYLFNCFTTELPWASCGHYWNTENCVD-------------FN-------NESIANFTNPYSTSPV 189

  Fly   228 KEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTIL 292
            .||||||.|:||.||||:|.:|||||..|.:.|::||||||||.|.||||||.||.|||.:|.||
Zfish   190 MEFWERRVLKISSGIEEVGGLRWELALCLAIAWVICYFCIWKGPKSTGKVVYVTATFPYFMLLIL 254

  Fly   293 LVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKD 357
            |:||||||||..|||||:.|:.|:|::.:||:||.|||||||.:.||.|.||||||.:.||.|:|
Zfish   255 LLRGITLPGAANGIKFYLYPDISRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNSYNNNCYRD 319

  Fly   358 ALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCL 422
            .|::|.:||.||..|||.||||:||||:||..|:..||.|||||||:.||.||..:|.:|:|:.|
Zfish   320 CLMLCCLNSGTSFVAGFAIFSVLGFMAYEQNVPIEAVAESGPGLAFIAYPKAVTMMPWAPLWAAL 384

  Fly   423 FFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLR--KRKEIFIAIVCALSYLVGLTCITQGGMYIF 485
            ||.||:.:||||||..:|..:|||:|.:|:..|  .|:|:.|..:...|:.:||..:|:||||:|
Zfish   385 FFMMLIFLGLDSQFVCVESLVTAIVDMYPKTFRVGYRRELLILGMSIASFFLGLIMLTEGGMYVF 449

  Fly   486 QILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVF 550
            |:.||||.||.|||::..||.:.|.|.||.||||..|:|||||.|..:.|:||...||.||.|:|
Zfish   450 QLFDSYAASGMCLLFVAIFESICIGWVYGSDRFYLNIEDMIGYKPIFFIKWCWKFFTPGICTGIF 514

  Fly   551 FFNIVQWTPVKYLD-YSYPWWAHAFGWFTALSSMLYIPL-YMFWLWKRTPGELSEKIRALVRIDE 613
            .|.::::.|:||.: |:||.|.:..||..|:|||:.||| .:|.:|| |.|...|:|:.|.....
Zfish   515 LFFLIKYKPLKYNNVYTYPDWGYGIGWMMAMSSMVCIPLGILFQIWK-TKGTFRERIKKLTTPSA 578

  Fly   614 DVTRLR 619
            |: |:|
Zfish   579 DL-RMR 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	295/557 (53%)
slc6a11b	XP_017213744.2	SLC5-6-like_sbd	38..576	CDD:320982	295/558 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920