Protein Alignment Gat and slc6a18

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001108369.2
• Gene: slc6a18 / 100141332
• ZFINID: ZDB-GENE-080219-9
• Length: 618
• Species: Danio rerio
• Alignment Length: 639
• Identity: 220/639 - (34%)
• Similarity: 328/639 - (51%)
• Gaps: 133/639 - (20%)

  Fly    39 TTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIIT 103
            |.::||:.|         :|..|.:|:.::|:.||.|:||||:|||||||...|||||::||:|.
Zfish     3 TASETSSVQ---------ERPKWDNKVQYLLTCVGFAVGLGNIWRFPYLCQIYGGGAFLIPYLIA 58

  Fly   104 LFLAGIPMFFMELALGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFM 167
            |...|:|:.::|||:||.|..|.:||: .|:|:..|:|.|:.|:|..:.::|..||||.::|||.
Zfish    59 LVFEGLPLLYLELAIGQSLRKGSIGVWHSISPLLGGVGVASMVVSFLVGLFYNTILAWVLWYFFH 123

  Fly   168 SMRADVPWRTC---NNWWNTV-NCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVK 228
            |....:||..|   :|....| .|||                                  :.||.
Zfish   124 SFEDPLPWSQCPINDNLEGYVEECVS----------------------------------STPVN 154

  Fly   229 EFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILL 293
            .:|.|:.|.||..||:.|:::|.|...|...|.:.|.|..:|::..||.||.||.|||::|||.|
Zfish   155 YYWYRQTLNISPDIEQSGSLQWTLVLCLATAWSIVYICFIRGIETIGKAVYVTATFPYLVLTIFL 219

  Fly   294 VRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDA 358
            ||.:|||||.:|:::...|::|.|||.:||:||.||||||..|..|.|:|..|||...|:..:||
Zfish   220 VRALTLPGATDGLQYLFTPDWSLLTNPQVWLDAATQIFFSLSLAFGGLIAFSSYNPKKNDCERDA 284

  Fly   359 LIVCTVNSSTSMFAGFVIFSVIGFMA--------------------------------------- 384
            |.|..:||:||::|...||:::||.|
Zfish   285 LFVGIINSATSLYASIPIFAILGFKATSNFNSCVNSNILDLTNAFDIGDRNITIENYDSWLRDLN 349

  Fly   385 -------------HEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQF 436
                         |...:...|.:|||.||||:|:..||:::|||.:|:.|||.||..:||.|.|
Zfish   350 ASDPDRVSSLNLKHCVLKNFLDQSASGTGLAFIVFTEAVIEMPGSQVWAVLFFVMLFSLGLSSMF 414

  Fly   437 CTMEGFITAIID-----EWPQLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGF 496
            ..:||.:|.::|     .|     ..||||..::|.:::||.|......|.|..:|.:|| |...
Zfish   415 GNLEGVLTPLLDLHMVPRW-----MPKEIFTGLICVVNFLVALIFTLGSGNYWLEIFNSY-VGSV 473

  Fly   497 CLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFF-FNIVQ---- 556
            .||.:.|||.:::...||:.||.|.|:.|.|..|.::|:.||...:|.:.|.|.. :.:||
Zfish   474 PLLVIAFFEIIAVVCFYGIKRFSDDIEQMTGRRPNLFWRCCWMGISPVMLLVVLVAYVVVQVQKH 538

  Fly   557 -----WTPVKYLDY------SYPWWAHAFGWFTALSS--MLYIPLY-MFWLWKR 596
                 |.| :|.::      .|..|  .|.....|||  ::.||:. ::.|.:|
Zfish   539 PTYPAWNP-QYENFPETEEKPYSTW--VFSICVLLSSVPVISIPIVALYRLMRR 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	216/620 (35%)
slc6a18	NP_001108369.2	None