DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mav and GDF5

DIOPT Version :9

Sequence 1:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_000548.2	Gene:	GDF5 / 8200	HGNCID:	4220	Length:	501	Species:	Homo sapiens

Alignment Length:	231	Identity:	53/231 - (22%)
Similarity:	100/231 - (43%)	Gaps:	32/231 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 WIEFDVTKAVRSWLNKSHENLGIEIQC-DKCKSIGARILSDFSPSTPPRSTASSDEHLNLMPVLN 544
            |..||:.|..|::.|.:  .|.:|::. ::.:::..|.|.        ...|:...|...:.::
Human   291 WEVFDIWKLFRNFKNSA--QLCLELEAWERGRAVDLRGLG--------FDRAARQVHEKALFLV- 344

  Fly   545 IIGHGTLNSQQHGDADIHQIMLTNNRSDQYVH-------HRSNHDSTWRKDKWTNNCYKLHQRCC 602
                  ....:..|...::|...:.:.|:.|:       .:.......|:.|..:.  .|..||.
Human   345 ------FGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSK--NLKARCS 401

  Fly   603 RNQLDVAFKSIKGFEFILQPKVFDAGYCHGRC--PPR-HNPAHHHALLQSLIWQEDHKRAPRPCC 664
            |..|.|.||.:...::|:.|..::|.:|.|.|  |.| |....:||::|:|:...|.:..|..||
Human   402 RKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCC 466

  Fly   665 TPSKLEMLEILHVDENHSDKLKISTWSDMQVVECAC 700
            .|::|..:.||.:|.  ::.:....:.||.|..|.|
Human   467 VPTRLSPISILFIDS--ANNVVYKQYEDMVVESCGC 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	8/24 (33%)
mav	NP_524626.1	TGF_beta	599..700	CDD:278448	33/103 (32%)
GDF5	NP_000548.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..169
		TGFb_propeptide	145..344	CDD:279078	12/62 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..265
		TGFB	400..501	CDD:214556	33/103 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810