DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mav and gdf10b

DIOPT Version :9

Sequence 1:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_001165060.2	Gene:	gdf10b / 794493	ZFINID:	ZDB-GENE-120316-1	Length:	385	Species:	Danio rerio

Alignment Length:	259	Identity:	55/259 - (21%)
Similarity:	89/259 - (34%)	Gaps:	63/259 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 QDTMNILLHFPLTNAQDANFHHDKIDEANVRLMLLYS-SSLATNFR----RGPGSR-----KNKI 415
            :.|....|.||   |.||:.|.|.|:.:.......|. :||...|.    ..|.|.     :.|.
Zfish   119 EKTHKCTLDFP---AVDASVHKDVIEVSFKHPSAFYERASLEEEFEYTIILNPSSSSVPHLQEKS 180

  Fly   416 SQISGNDNIERHCNFGDVNLNQSNKNSSQQLTLKVYQLLSANRRRKITSRKIE-FGNVGFQE--- 476
            |.....|.:...|. ..|::|||          .|.|.:......||.|..:. :.||...:
Zfish   181 SHSCFEDELGYLCE-TKVHVNQS----------VVVQWVVLKFEGKIASIPVHTYKNVSVPQLEP 234

  Fly   477 --TRTQWIEFDVTKAVR--------SWLNKSHENLGIEIQCDKCKSIGARIL-----SDFS-PST 525
              .:|:||...:..::.        .|.  .|:|..   :..|..||...|:     :.:| |.:
Zfish   235 ASAKTEWIAAILCGSIALLFIVFVVLWF--IHKNFS---KIPKVPSILRNIVTRPYSTPYSQPES 294

  Fly   526 PPRSTASSDEH-----LNLMPVLNIIGHGTLNSQQHGDADIHQIMLTNNRSDQYVHHRSNHDST 584
            |..|:.:|..|     .|..|:|:.:         |.:.......|.|...::.......:||:
Zfish   295 PHVSSMTSATHTPVLLYNNEPLLDFV---------HDEVSKTTDTLVNTEEEEPAPSEEEYDSS 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	13/77 (17%)
mav	NP_524626.1	TGF_beta	599..700	CDD:278448
gdf10b	NP_001165060.2	FN3	21..104	CDD:328772
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810