Protein Alignment mav and LEFTY2

DIOPT Version :9

• Sequence 1: NP_524626.1
• Gene: mav / 43804
• FlyBaseID: FBgn0039914
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_003231.2
• Gene: LEFTY2 / 7044
• HGNCID: 3122
• Length: 366
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 84/474 - (17%)
• Similarity: 160/474 - (33%)
• Gaps: 153/474 - (32%)

  Fly   244 PSKRVDETRLKHLVLKGLGIKKLP-----DMRKVNISQAEYSSKYIEYLSRLRSNQEKGNSYFNN 303
            |...:.|.:|...:|:.|.:.::|     ||.|: :..|...::|:..|.|...::.:|..:
Human    18 PGAALTEEQLLGSLLRQLQLSEVPVLDRADMEKL-VIPAHVRAQYVVLLRRSHGDRSRGKRF--- 78

  Fly   304 FMGASFTRDLHFLSITTNGFNDISNKRLRHRRSLKKINRLNQNPKKHQNYGDLLRGEQDTMNILL 368
                            :..|.:::                          |..|..|..|.  ||
Human    79 ----------------SQSFREVA--------------------------GRFLASEASTH--LL 99

  Fly   369 HFPLTNAQDANFHHDKIDEANVRLMLLYSSSLATNFRRGPGSRKNKISQISGNDNIERHCNFGDV 433
            .|.:......|   .::.:|.:||.                  :..:.:.:    :.||...
Human   100 VFGMEQRLPPN---SELVQAVLRLF------------------QEPVPKAA----LHRHGRL--- 136

  Fly   434 NLNQSNKNSSQQLTLKVYQLL--SANRRRKITSRKIEFGNVGFQETRTQWIEFDVTKAVRSW--L 494
                |.:::..::|::..::.  .:||...|.||.:.....|       |..||||:||..|  |
Human   137 ----SPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESG-------WKAFDVTEAVNFWQQL 190

  Fly   495 NKSHENLGIEIQCDK----CKSIGARILSDFSPSTPPRSTASSDEHLNLMPVLNIIGHGTLNSQQ 555
            ::..:.|.:::...:    ..:.||..|..|:....|.........|:   .|::..:|.
Human   191 SRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELH---TLDLRDYGA----- 247

  Fly   556 HGDADIHQIMLTNNRSDQYVHHRSNHDSTWRKDKWTNNCYKLHQRCCRNQLDVAFKSIK-GFEFI 619
            .||.|....|....                              ||||.::.:..:.:| ...::
Human   248 QGDCDPEAPMTEGT------------------------------RCCRQEMYIDLQGMKWAKNWV 282

  Fly   620 LQPKVFDAGYCHGRC--PPRHNPAHHHALLQSLIWQEDHKRAPRPCCTPSKLEMLEILHVDENHS 682
            |:|..|.|..|.|.|  ||       .||  :..|.   ...||.|.......:..|:.:.|...
Human   283 LEPPGFLAYECVGTCQQPP-------EAL--AFNWP---FLGPRQCIASETASLPMIVSIKEGGR 335

  Fly   683 DKLKISTWSDMQVVECACS 701
            .:.::.:..:|:|.:|:|:
Human   336 TRPQVVSLPNMRVQKCSCA 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	17/67 (25%)
		TGF_beta	599..700	CDD:278448	25/103 (24%)
LEFTY2	NP_003231.2	TGFb_propeptide	<106..214	CDD:307025	24/146 (16%)
		TGF_beta	263..353	CDD:306518	24/101 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810