Protein Alignment mav and TGFB3

DIOPT Version :10

• Sequence 1: NP_524626.1
• Gene: mav / 43804
• FlyBaseID: FBgn0039914
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_003230.1
• Gene: TGFB3 / 7043
• HGNCID: 11769
• Length: 412
• Species: Homo sapiens
• Alignment Length: 441
• Identity: 102/441 - (23%)
• Similarity: 174/441 - (39%)
• Gaps: 96/441 - (21%)

  Fly   310 TRDLHFLSITTNGFNDISNKRLRHRRS--LKKINRLNQNPKKHQNYGDLLRGEQDTMNILLHFP- 371
            |..|...:.||..|..|..||:...|.  |.|: ||...|:.               .::.|.|
Human    19 TVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKL-RLTSPPEP---------------TVMTHVPY 67

  Fly   372 ----LTNA--------------------QDANFHHDKIDEANVRLMLLYSSSLATNFRRGPGSR- 411
                |.|:                    .::.::..:|.:.::...|...:.||. ..:|..|:
Human    68 QVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAV-CPKGITSKV 131

  Fly   412 -KNKISQISGNDNIERHCNFGDVNL-NQSNKNSSQQLTLKVYQLLSAN----RRRKITSRKIEFG 470
             :..:|.:..|........|..:.: |.|:|.:.|::.|  :|:|..:    ::|.|..:.:
Human   132 FRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIEL--FQILRPDEHIAKQRYIGGKNL--- 191

  Fly   471 NVGFQETR--TQWIEFDVTKAVRSWLNKSHENLGIE--IQCDKCKSIGARILSDFSPSTPPRSTA 531
                 .||  .:|:.||||..||.||.:...|||:|  |.| .|.:        |.|
Human   192 -----PTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHC-PCHT--------FQP-------- 234

  Fly   532 SSDEHLNLMPVLNIIGHGTLNSQQHGDADIHQIMLTNNRSDQYV-------HHRSNHDSTWRKDK 589
            :.|...|:..|:.|...|..|...||..|:.::....:..:.::       |...|.....::.|
Human   235 NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKK 299

  Fly   590 W---TNNCYK-LHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCPPRHNPAHHHALLQSL 650
            .   ||.|:: |.:.||...|.:.|:...|::::.:||.:.|.:|.|.||...:....|:.:..|
Human   300 RALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGL 364

  Fly   651 IWQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECACS 701
            ....:.:.:..|||.|..||.|.||:......   |:...|:|.|..|.||
Human   365 YNTLNPEASASPCCVPQDLEPLTILYYVGRTP---KVEQLSNMVVKSCKCS 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<438..518	CDD:480997	26/87 (30%)
		TGF_beta_maverick	598..700	CDD:381633	28/101 (28%)
TGFB3	NP_003230.1	TGFb_propeptide	24..231	CDD:459906	52/234 (22%)
		Cell attachment site. /evidence=ECO:0000250|UniProtKB:P01137	261..263		0/1 (0%)
		TGF_beta_TGFB3	312..412	CDD:381656	28/102 (27%)