DRSC/TRiP Functional Genomics Resources

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Protein Alignment mav and TGFB2

DIOPT Version :9

Sequence 1:NP_524626.1 Gene:mav / 43804 FlyBaseID:FBgn0039914 Length:701 Species:Drosophila melanogaster
Sequence 2:NP_001129071.1 Gene:TGFB2 / 7042 HGNCID:11768 Length:442 Species:Homo sapiens


Alignment Length:296 Identity:79/296 - (26%)
Similarity:124/296 - (41%) Gaps:67/296 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   437 QSNKNSSQQLTLKVYQLLSANRRRKITSRKIEFGNVGFQETRT--QWIEFDVTKAVRSWLNKSHE 499
            |:.|....:..:::||:|.:......|.|.|:...|   :||.  :|:.||||.||..||:....
Human   183 QNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVV---KTRAEGEWLSFDVTDAVHEWLHHKDR 244

  Fly   500 NLG--IEIQCDKCKSIGAR--ILSDFSPSTPPR-------STASSDE----------------HL 537
            |||  |.:.|..|..:.:.  |:.:.|.....|       ||.:|.:                ||
Human   245 NLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHL 309

  Fly   538 NLMPVLNIIGHGTLNSQQHGDADIHQIMLTNNRSDQYVHHRSNHDSTWRKDKWTNNCYK-LHQRC 601
            .||    ::....|.|||           ||.|..:.:      |:.:        |:: :...|
Human   310 LLM----LLPSYRLESQQ-----------TNRRKKRAL------DAAY--------CFRNVQDNC 345

  Fly   602 CRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCPPRHNPAHHHALLQSLIWQEDHKRAPRPCCTP 666
            |...|.:.||...|:::|.:||.::|.:|.|.||...:....|:.:.||....:.:.:..|||..
Human   346 CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVS 410

  Fly   667 SKLEMLEILHVDENHSDKL-KISTWSDMQVVECACS 701
            ..||.|.||:    :..|. ||...|:|.|..|.||
Human   411 QDLEPLTILY----YIGKTPKIEQLSNMIVKSCKCS 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mavNP_524626.1 TGFb_propeptide <442..506 CDD:279078 22/67 (33%)
TGF_beta 599..700 CDD:278448 32/101 (32%)
TGFB2NP_001129071.1 TGFb_propeptide 21..256 CDD:395559 25/75 (33%)
TGF_beta_TGFB2 345..441 CDD:381655 32/99 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3900
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1343
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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