Protein Alignment mav and BMP4

DIOPT Version :10

• Sequence 1: NP_524626.1
• Gene: mav / 43804
• FlyBaseID: FBgn0039914
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_001334841.1
• Gene: BMP4 / 652
• HGNCID: 1071
• Length: 455
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 113/569 - (19%)
• Similarity: 201/569 - (35%)
• Gaps: 155/569 - (27%)

  Fly   154 ETNQHPIIRAKSTPKMGLKNVFESFSKQSRDSIYNASSNKYSLINV------SQSKNFPQLFNKK 212
            |...|.::.:::|........|:...  ||.::.|.....|:|.:|      |.:...|:...||
Human    19 EARSHSVVPSRATHCCSFPEPFQQVC--SRLAVKNHGLLLYALFSVILLGGASHASLIPETGKKK 81

  Fly   213 LSVQWINTVPIQSRQTRE-TRD--------IGLETKRHSKPSKRVDETRLKHLVLKGLGIKKLPD 268
            ::....:....:|.|:.| .||        .||  :|..:|||..                .:||
Human    82 VAEIQGHAGGRRSGQSHELLRDFEATLLQMFGL--RRRPQPSKSA----------------VIPD 128

  Fly   269 MRKVNISQAEYSSKYIEYLSRLRSNQEKGNSYFNNFMGASFTRDLHFLSITTNGFNDISNKRLRH 333
                          |:..|.||:|.:|:.....:.  |..:.......:.|...|:
Human   129 --------------YMRDLYRLQSGEEEEEQIHST--GLEYPERPASRANTVRSFH--------- 168

  Fly   334 RRSLKKINRLNQNPKKHQNYGDLLRGEQDTMNILLHFPLTNAQDANFHHDKIDEANVRLMLLYSS 398
                            |:.:.:.:.|..:.......|.|::..:    ::.|..|.:||
Human   169 ----------------HEEHLENIPGTSENSAFRFLFNLSSIPE----NEVISSAELRL------ 207

  Fly   399 SLATNFRRGPGSRKNKISQISGNDNIERHCNFGDVNLNQSNKNSSQQLTLKVYQLLSANRRRKIT 463
                 ||          .|:....:.||  .|..:|:.:..|..:        :::..:...::.
Human   208 -----FR----------EQVDQGPDWER--GFHRINIYEVMKPPA--------EVVPGHLITRLL 247

  Fly   464 SRKIEFGNVGFQETRTQWIEFDVTKAVRSWLNKSHENLGIEIQCDKCKSI----GARILSDFSPS 524
            ..::...||      |:|..|||:.||..|..:...|.|:.|:.......    |..:  ..|.|
Human   248 DTRLVHHNV------TRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHV--RISRS 304

  Fly   525 TPPRSTASSDEHLNLMPVLNIIGHGTLNSQQHGDADIHQIMLTNNRSDQYVHHRSNHDSTWRKDK 589
            .|    ..|.....|.|:|...||         |...|.:...........||
Human   305 LP----QGSGNWAQLRPLLVTFGH---------DGRGHALTRRRRAKRSPKHH------------ 344

  Fly   590 WTNNCYKLHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCP---PRHNPAHHHALLQSLI 651
             :....|.::.|.|:.|.|.|..:...::|:.|..:.|.||||.||   ..|..:.:||::|:|:
Human   345 -SQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLV 408

  Fly   652 WQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECAC 700
             ...:...|:.||.|::|..:.:|::||  .||:.:..:.:|.|..|.|
Human   409 -NSVNSSIPKACCVPTELSAISMLYLDE--YDKVVLKNYQEMVVEGCGC 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<438..518	CDD:480997	15/83 (18%)
		TGF_beta_maverick	598..700	CDD:381633	32/104 (31%)
BMP4	NP_001334841.1	TGFb_propeptide	90..322	CDD:459906	59/337 (18%)
		TGF_beta_BMP4_BMP2B	349..455	CDD:381661	34/109 (31%)