DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mav and BMP2

DIOPT Version :9

Sequence 1:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_001191.1	Gene:	BMP2 / 650	HGNCID:	1069	Length:	396	Species:	Homo sapiens

Alignment Length:	273	Identity:	70/273 - (25%)
Similarity:	124/273 - (45%)	Gaps:	54/273 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 NSSQQLTLKVYQLL---SANRRRKITSRKIEFGNVGFQETRTQWIEFDVTKAVRSWLNKSHENLG 502
            |||....:.:|:::   :||.:..:| |.::...|  .:..::|..||||.||..|..:.|.|.|
Human   164 NSSFHHRINIYEIIKPATANSKFPVT-RLLDTRLV--NQNASRWESFDVTPAVMRWTAQGHANHG 225

  Fly   503 IEIQ---CDKCKSIGARILSDFSPSTPPRSTAS--SDEH--LNLMPVLNIIGHGTLNSQQHGDAD 560
            ..::   .::.:.:..|.:         |.:.|  .|||  ..:.|:|...||         |..
Human   226 FVVEVAHLEEKQGVSKRHV---------RISRSLHQDEHSWSQIRPLLVTFGH---------DGK 272

  Fly   561 IHQIMLTNNRSDQYVHHRSNHDSTWRKDKWTNNCYKLHQRCCRNQLDVAFKSIKGFEFILQPKVF 625
            .|.:           |.|....:..::.|      :|...|.|:.|.|.|..:...::|:.|..:
Human   273 GHPL-----------HKREKRQAKHKQRK------RLKSSCKRHPLYVDFSDVGWNDWIVAPPGY 320

  Fly   626 DAGYCHGRCP---PRHNPAHHHALLQSLIWQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKLKI 687
            .|.||||.||   ..|..:.:||::|:|: ...:.:.|:.||.|::|..:.:|::|||  :|:.:
Human   321 HAFYCHGECPFPLADHLNSTNHAIVQTLV-NSVNSKIPKACCVPTELSAISMLYLDEN--EKVVL 382

  Fly   688 STWSDMQVVECAC 700
            ..:.||.|..|.|
Human   383 KNYQDMVVEGCGC 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	19/66 (29%)
mav	NP_524626.1	TGF_beta	599..700	CDD:278448	33/103 (32%)
BMP2	NP_001191.1	TGFb_propeptide	37..267	CDD:279078	28/114 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..121
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..293		4/38 (11%)
		TGFB	296..396	CDD:214556	34/103 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810