DRSC/TRiP Functional Genomics Resources

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Protein Alignment mav and Tgfb1

DIOPT Version :9

Sequence 1:NP_524626.1 Gene:mav / 43804 FlyBaseID:FBgn0039914 Length:701 Species:Drosophila melanogaster
Sequence 2:NP_067589.1 Gene:Tgfb1 / 59086 RGDID:69051 Length:390 Species:Rattus norvegicus


Alignment Length:270 Identity:78/270 - (28%)
Similarity:121/270 - (44%) Gaps:51/270 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   442 SSQQLTLKVYQLLSANRRRKITSRKIEFGNVGFQETRT-QWIEFDVTKAVRSWLNKSHENLGIEI 505
            |:.:..:::||..|.|..|.:       ||.....|.| :|:.||||..||.|||:..   ||: 
  Rat   162 STVEQHVELYQKYSNNSWRYL-------GNRLLTPTDTPEWLSFDVTGVVRQWLNQGD---GIQ- 215

  Fly   506 QCDKCKSIGARILSDFSPSTPPRSTASSDEHLNLMPVLNIIGHGTLNSQQHGD-ADIHQ------ 563
                    |.|    ||      :..|.|...|   ||::..:| ::.::.|| ..||.      
  Rat   216 --------GFR----FS------AHCSCDSKDN---VLHVEING-ISPKRRGDLGTIHDMNRPFL 258

  Fly   564 -IMLTNNRSDQYVHHRSNHDSTWRKDKWTNNCY-KLHQRCCRNQLDVAFKSIKGFEFILQPKVFD 626
             :|.|.....|:: |.|.|    |:...||.|: ...:.||..||.:.|:...|:::|.:||.:.
  Rat   259 LLMATPLERAQHL-HSSRH----RRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYH 318

  Fly   627 AGYCHGRCPPRHNPAHHHALLQSLIWQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKLKISTWS 691
            |.:|.|.||...:....::.:.:|..|.:...:..|||.|..||.|.|::.   ...|.|:...|
  Rat   319 ANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASASPCCVPQALEPLPIVYY---VGRKPKVEQLS 380

  Fly   692 DMQVVECACS 701
            :|.|..|.||
  Rat   381 NMIVRSCKCS 390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mavNP_524626.1 TGFb_propeptide <442..506 CDD:279078 22/64 (34%)
TGF_beta 599..700 CDD:278448 30/100 (30%)
Tgfb1NP_067589.1 TGFb_propeptide 30..261 CDD:395559 36/131 (27%)
Straightjacket domain. /evidence=ECO:0000250|UniProtKB:P07200 30..74
Arm domain. /evidence=ECO:0000250|UniProtKB:P07200 75..271 39/141 (28%)
Bowtie tail. /evidence=ECO:0000250|UniProtKB:P01137 226..252 8/29 (28%)
Cell attachment site. /evidence=ECO:0000255 244..246 0/1 (0%)
TGF_beta_TGFB1 292..390 CDD:381654 30/100 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3900
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1343
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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