Protein Alignment mav and NODAL

DIOPT Version :10

• Sequence 1: NP_524626.1
• Gene: mav / 43804
• FlyBaseID: FBgn0039914
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_060525.3
• Gene: NODAL / 4838
• HGNCID: 7865
• Length: 347
• Species: Homo sapiens
• Alignment Length: 235
• Identity: 59/235 - (25%)
• Similarity: 91/235 - (38%)
• Gaps: 61/235 - (25%)

  Fly   485 DVTKAVRSWLNKSHENLGIEIQCDKCKSIGARILSDF--SPSTPPRSTASSDEHLNLMPVLNIIG 547
            :||:.:..||  .|.. .:|.|.       :|:..:.  .|.|||.:......:.||......:|
Human   154 EVTRPLSKWL--KHPG-ALEKQM-------SRVAGECWPRPPTPPATNVLLMLYSNLSQEQRQLG 208

  Fly   548 HGTLNSQQHGDADIHQIMLTNNRSDQYVHHRSNHDSTWRKD------KWTNNCYKLH-----QRC 601
            ..||..:.                          :|:||..      :|.....:.|     |.|
Human   209 GSTLLWEA--------------------------ESSWRAQEGQLSWEWGKRHRRHHLPDRSQLC 247

  Fly   602 CRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCPPRHNPA----H--HHALLQSLIWQEDHKRAP 660
            .:.:..|.|..|....:|:.||.::|..|.|.||   ||.    |  :||.:|||:.:....|.|
Human   248 RKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECP---NPVGEEFHPTNHAYIQSLLKRYQPHRVP 309

  Fly   661 RPCCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECAC 700
            ..||.|.|.:.|.:|:||   :.::.:....||.|.||.|
Human   310 STCCAPVKTKPLSMLYVD---NGRVLLDHHKDMIVEECGC 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<438..518	CDD:480997	8/32 (25%)
		TGF_beta_maverick	598..700	CDD:381633	37/112 (33%)
NODAL	NP_060525.3	TGF_beta_NODAL	245..346	CDD:381637	36/106 (34%)