DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mav and GDF6

DIOPT Version :9

Sequence 1:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_001001557.1	Gene:	GDF6 / 392255	HGNCID:	4221	Length:	455	Species:	Homo sapiens

Alignment Length:	108	Identity:	36/108 - (33%)
Similarity:	56/108 - (51%)	Gaps:	5/108 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   596 KLHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRC--PPR-HNPAHHHALLQSLIWQEDHK 657
            |...||.:..|.|.||.:...::|:.|..::|.:|.|.|  |.| |....:||::|:|:...|..
Human   349 KSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPG 413

  Fly   658 RAPRPCCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECAC 700
            ..|..||.|:||..:.||::|..::...|  .:.||.|..|.|
Human   414 STPPSCCVPTKLTPISILYIDAGNNVVYK--QYEDMVVESCGC 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078
mav	NP_524626.1	TGF_beta	599..700	CDD:278448	34/103 (33%)
GDF6	NP_001001557.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..93
		TGFb_propeptide	79..281	CDD:395559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..267
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..351		1/1 (100%)
		TGF_beta_GDF5_6_7	354..455	CDD:381644	34/103 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810