DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mav and INHBB

DIOPT Version :9

Sequence 1:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_002184.2	Gene:	INHBB / 3625	HGNCID:	6067	Length:	407	Species:	Homo sapiens

Alignment Length:	299	Identity:	68/299 - (22%)
Similarity:	113/299 - (37%)	Gaps:	89/299 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 NQSNKN-----SSQQLTLKVY-QLLSANRRRKITSRKIEFGNVGFQE----------------TR 478
            |:.|:|     :|..|.||:. .:|....|||:..:      |.|||                .|
Human   165 NEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVK------VYFQEQGHGDRWNMVEKRVDLKR 223

  Fly   479 TQWIEFDVTKAVRSWLNKSHENLGIEIQCDKCKSIGARILSDFSPSTPPRSTASSDEHLNLMPVL 543
            :.|..|.:|:|:::...:....|.:::|||.|                        :.|.::||.
Human   224 SGWHTFPLTEAIQALFERGERRLNLDVQCDSC------------------------QELAVVPVF 264

  Fly   544 NIIGHGTLNSQQHGDADIHQIMLTNNRSDQYVHHRSNHDSTWRK-----DKWTNNCYKLHQRCCR 603
            ...|     .:.|....:.|..|.::|      ||.      ||     |..||       .|||
Human   265 VDPG-----EESHRPFVVVQARLGDSR------HRI------RKRGLECDGRTN-------LCCR 305

  Fly   604 NQLDVAFKSIKGFEFILQPKVFDAGYCHGRCP------PRHNPAHHHALLQSLIWQEDHKRAPRP 662
            .|..:.|:.|...::|:.|..:...||.|.||      |....:.|.|::.....:..:......
Human   306 QQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGTVNS 370

  Fly   663 CCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECACS 701
            ||.|:||..:.:|:.|:.::  :......:|.|.||.|:
Human   371 CCIPTKLSTMSMLYFDDEYN--IVKRDVPNMIVEECGCA 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	18/80 (23%)
mav	NP_524626.1	TGF_beta	599..700	CDD:278448	27/106 (25%)
INHBB	NP_002184.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..62
		TGFb_propeptide	57..278	CDD:279078	30/147 (20%)
		TGFB	303..406	CDD:214556	27/104 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810