DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mav and INHBA

DIOPT Version :9

Sequence 1:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	XP_016867663.1	Gene:	INHBA / 3624	HGNCID:	6066	Length:	548	Species:	Homo sapiens

Alignment Length:	600	Identity:	117/600 - (19%)
Similarity:	205/600 - (34%)	Gaps:	171/600 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 ENEAKRLETNQHPIIRAKSTPKMGLKNVFESFSKQSRDSIYNASSNKYSLINVSQSKNFPQLFNK 211
            ||..||.        |.|.|||..:|....: .|.:|:....|...| ..|..:.:...|.|:.:
Human    75 ENLLKRR--------RKKKTPKKKIKKSTHT-KKPAREGGGKAGPFK-KAITTTFAARMPLLWLR 129

  Fly   212 --KLSVQWI--NTVPIQSRQTRET-------------RDIGLETKRHSKPSKRVDETRLKHLVLK 259
              .|:..||  .:.|....:....             :|:     .:|:|  .:.|...|| :|.
Human   130 GFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDV-----PNSQP--EMVEAVKKH-ILN 186

  Fly   260 GLGIKKLPDMRKVNISQAEYSSKYIEYLSRLRSNQEKGNSYFNNFMGASFTRDLHFLSITTNGFN 324
            .|.:||.||     ::|....:..:..:                       |.||...:..||:.
Human   187 MLHLKKRPD-----VTQPVPKAALLNAI-----------------------RKLHVGKVGENGYV 223

  Fly   325 DISNKRLRHRRSLKKINRLNQNPKKHQNYGDLLRGEQDTMNILLHFPLT-NAQDANFHHDKIDEA 388
            :|.:...|         |...|....|....:...|..|....|||.:: ...|.:.    ::.|
Human   224 EIEDDIGR---------RAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSV----VERA 275

  Fly   389 NVRLMLLYSSSLATNFRRGPGSRKNKISQISGNDNIERHCNFGDVNLNQSNKN---------SSQ 444
            .|.|.|....:..|         :.|::                :.|.|..|:         .::
Human   276 EVWLFLKVPKANRT---------RTKVT----------------IRLFQQQKHPQGSLDTGEEAE 315

  Fly   445 QLTLKVYQLLSANRRRKITSRKIEFGNVGFQETRTQWIEFDVTKAVRSWLNKSHENLGIEIQCDK 509
            ::.||      ..|...:.|.|:      ....::.|..|.|:.:::..|::...:|.:.|.|::
Human   316 EVGLK------GERSELLLSEKV------VDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQ 368

  Fly   510 CKSIGARILSDFSPSTPPRSTASSDEHLNLMPVLNIIGHGTLNSQQHGDADIHQIMLTNNRSDQY 574
            |:..||.::      ...:.....:|           |.|.......|.|...:....::|....
Human   369 CQESGASLV------LLGKKKKKEEE-----------GEGKKKGGGEGGAGADEEKEQSHRPFLM 416

  Fly   575 VHHRSNHDSTWRKDKWTNNCYKLHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCPPR-- 637
            :..|.:.|...|:.:....|......||:.|..|:||.|...::|:.|..:.|.||.|.||..
Human   417 LQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIA 481

  Fly   638 ---------HNPAHHHALLQSLIWQEDHKRAP----RPCCTPSKLEMLEILHVDENHSDKLKIST 689
                     |:...:|..::.        .:|    :.||.|:||..:.:|:.|:..:...|
Human   482 GTSGSSLSFHSTVINHYRMRG--------HSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKK--- 535

  Fly   690 WSDMQ---VVECACS 701
              |:|   |.||.||
Human   536 --DIQNMIVEECGCS 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	10/63 (16%)
mav	NP_524626.1	TGF_beta	599..700	CDD:278448	31/118 (26%)
INHBA	XP_016867663.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810