DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mav and bmp7a

DIOPT Version :9

Sequence 1:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_571396.1	Gene:	bmp7a / 30584	ZFINID:	ZDB-GENE-000208-25	Length:	432	Species:	Danio rerio

Alignment Length:	468	Identity:	101/468 - (21%)
Similarity:	174/468 - (37%)	Gaps:	119/468 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 GNSYFNNFMGASFTRDLHFLSITTNGFNDI----------SNKRLRHRRSLKKINRLNQNPKK-- 349
            |.|...:.|.|:||.|           |||          |.:|...:|.:..|..|.|.|:.
Zfish    19 GCSVLADAMQANFTMD-----------NDIQSSFIQRRLKSQERREMQREILSILGLPQRPRPLL 72

  Fly   350 HQNYGDLLRGEQDTMNILLHF--------------------PLTNAQDANFHHD---------KI 385
            |:.:........|..|.:|..                    ||...||:.|..|         .:
Zfish    73 HERHTAAPMYMLDLYNAILEDGDRRGGLVYSYEPAYTTPGPPLVTQQDSRFLSDADMVMSFANTV 137

  Fly   386 D-EANVRLMLLYSSSLATNFRRGPGSRKNKISQISGNDNIERHCNFGDVNLNQSNKNSSQQLTLK 449
            | |.:::|...:......:..|.|.......::.....:..|            .:..::...:.
Zfish   138 DPEEDLQLYHQHRREFRFDLSRIPPGETVTAAEFRIYKDFVR------------ERYENETFHVS 190

  Fly   450 VYQLLSANRRRK---ITSRKIEFGNVGFQETRTQWIEFDVTKAVRSWLNKSHENLGIEIQCDKCK 511
            |:|:|....||:   :.||.:.....|       |:.||:|.....|:....:|||:::..:  .
Zfish   191 VFQVLQQQHRRELYLLDSRVVWAAEEG-------WLVFDLTVTSNHWVINPGQNLGLQLLVE--T 246

  Fly   512 SIGARILSDFSPSTPPRSTASSDEHLNLMPVLNIIG-HGTLNSQQHGDADIHQ--IMLTNNRS-- 571
            |.|||:       .|.|:              .::| .|..|.|....|.:..  |.|.:.||
Zfish   247 SHGARM-------NPRRA--------------GLVGSSGAQNKQPFMVAFLKASGIHLRSVRSAS 290

  Fly   572 --DQYVHHRSN-------HDSTWRKDKWTNNCYKL--HQRCCRNQLDVAFKSIKGFEFILQPKVF 625
              .|..|||:.       |.....|.........:  .|.|.:::|.|:|:.:...::|:.|:.:
Zfish   291 GGKQKGHHRTKNAKPGAAHSQVALKTAEATEGASIDPKQGCKKHELYVSFRDLGWQDWIIAPEGY 355

  Fly   626 DAGYCHGRCPPRHNP---AHHHALLQSLIWQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKLKI 687
            .|.||.|.|....|.   |.:||::|:|:...:.:..|:|||.|::|..:.:|:.|:  |..:.:
Zfish   356 AAYYCEGECVFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLHGISVLYFDD--SSNVIL 418

  Fly   688 STWSDMQVVECAC 700
            ..:.:|.|..|.|
Zfish   419 KKYRNMVVRACGC 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	16/66 (24%)
mav	NP_524626.1	TGF_beta	599..700	CDD:278448	30/103 (29%)
bmp7a	NP_571396.1	TGFb_propeptide	34..275	CDD:279078	53/293 (18%)
bmp7a	NP_571396.1	TGF_beta	329..431	CDD:278448	30/103 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910