Protein Alignment mav and lft1

DIOPT Version :10

• Sequence 1: NP_524626.1
• Gene: mav / 43804
• FlyBaseID: FBgn0039914
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_571035.1
• Gene: lft1 / 30145
• ZFINID: ZDB-GENE-990630-10
• Length: 358
• Species: Danio rerio
• Alignment Length: 471
• Identity: 92/471 - (19%)
• Similarity: 158/471 - (33%)
• Gaps: 167/471 - (35%)

  Fly   253 LKHLVLKGLGIKKLPDMRKVNISQAEYSSKYIEYLSRLRSNQEKGNSYFNNFMGASFTRDLHFLS 317
            :|..:||.||:.::|.:.|                                       |||..|.
Zfish    26 MKDALLKKLGLNEIPQIHK---------------------------------------RDLENLV 51

  Fly   318 ITTNGFND-ISNKRLRHRRSLKKINRLNQNPKKHQNYGDLLRG------------EQDTMNILLH 369
            |.|:..|. ||..:|.|.|..:.:..|          ..:|||            ..||....:.
Zfish    52 IPTHVKNKYISMLKLHHSRKRRSLPSL----------AGILRGIPGNADISGEFVYSDTTRQRVV 106

  Fly   370 FPLTNAQDANFHHDKIDEANVRLMLLYSSSLATNFRRGPGSRKNKISQISGNDNIERHCNFGDVN 434
            |.:|:....|   .::..|.::|           :::.|  .|..|.:..|:    |..|...|:
Zfish   107 FEMTSRIPEN---SEVTMAELKL-----------YKKAP--HKRSIPERKGH----RPVNNARVS 151

  Fly   435 LN--QSNKNSSQQLTLKVYQLLSANRRRKITSRKIEFGNVGFQETRTQWIEFDVTKAVRSWLNKS 497
            :.  :..|:.|             ||...:.||.|.....|       |..||||:||:.|....
Zfish   152 IYWVEPQKDGS-------------NRTSLVDSRLIPIHETG-------WKSFDVTQAVQYWSRSR 196

  Fly   498 HE---NLGIEIQCDKCKSIGARILS--DFSPSTPPRSTASSDEHLNLMPVLNIIGHGTLNSQQHG 557
            .|   :|.:.|:.::..|..|.:..  .|:...|..:|....| |.|.         |||.::.|
Zfish   197 MEMPMHLEVWIEGERPGSYAAEMAKCVHFTTQDPDDNTLGKPE-LVLY---------TLNLEEFG 251

  Fly   558 DADIHQIMLTNNRSDQYVHHRSNHDSTWRKDKWTNNCYKLHQRCCRNQLDVAFKSIKGFEF-ILQ 621
                                 |:.|....||:         :.|||.|..:.|:::...:: |::
Zfish   252 ---------------------SSGDCENNKDR---------EMCCREQYFINFRALTWTQYWIIE 286

  Fly   622 PKVFDAGYCHGRC-PPRHNPAHHHALLQSLIWQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKL 685
            |..:.|..|.|.| .|:.|..:                ..|.|.......:..:..|.:....::
Zfish   287 PSGYQAFRCKGGCRQPKRNYGY----------------GERKCAVVESAPLPMMYLVKKGDYTEI 335

  Fly   686 KISTWSDMQVVECACS 701
            :::.:.:|.|.:|.|:
Zfish   336 EVAEFPNMIVEKCGCA 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<438..518	CDD:480997	21/82 (26%)
		TGF_beta_maverick	598..700	CDD:381633	19/103 (18%)
lft1	NP_571035.1	TGFb_propeptide	24..>192	CDD:480997	52/254 (20%)
		TGF_beta_LEFTY1_2	265..350	CDD:381636	19/100 (19%)