Protein Alignment mav and GDF9

DIOPT Version :10

• Sequence 1: NP_524626.1
• Gene: mav / 43804
• FlyBaseID: FBgn0039914
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_005251.1
• Gene: GDF9 / 2661
• HGNCID: 4224
• Length: 454
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 89/456 - (19%)
• Similarity: 156/456 - (34%)
• Gaps: 150/456 - (32%)

  Fly   310 TRDLHFLS------ITTNGFNDISNKRLRHR-RSLKKINRLNQNPKKHQNYGDLLRGEQDTMNIL 367
            :|.||::.      .|..|....:...|.:. |......|..|.|      ||.:.|...::.:|
Human    83 SRALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPCTRHKQAP------GDQVTGILPSVELL 141

  Fly   368 LHFPLTNAQDANFHHDKID--EANVRLMLLYSSSLATNFRRGPGSRKNKISQISGNDNIERHCNF 430
                        |:.|:|.  |..::.:|||                |..:.:|.:..::..||.
Human   142 ------------FNLDRITTVEHLLKSVLLY----------------NINNSVSFSSAVKCVCNL 178

  Fly   431 GDVNLNQSNKNSSQQLTLKVYQLLSANRRRKITSRKIEFGNVGFQETRTQWIEFDVTKAVRSWL- 494
                :.:..|:||:.|....|..        ..:.:.|||.      :.:||:.|||..::..:
Human   179 ----MIKEPKSSSRTLGRAPYSF--------TFNSQFEFGK------KHKWIQIDVTSLLQPLVA 225

  Fly   495 -NKSHENLGIEIQC--DKCKSIGAR---------------ILSDFS---------------PSTP 526
             ||...::.|...|  |:.:...|:               .|:|.|               ||..
Human   226 SNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLVSPSLILYLNDTSAQAYHSWYSLHYKRRPSQG 290

  Fly   527 PRSTASSDEHLNLMPVLNIIGHGTLNSQQHGDADIHQIMLTNNRSDQYVHHRS------------ 579
            |    ..:..|:..||              |:.     ...:.||..:.|.|.
Human   291 P----DQERSLSAYPV--------------GEE-----AAEDGRSSHHRHRRGQETVSSELKKPL 332

  Fly   580 -----NHDSTWRKDKWTNNCYKLHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCPPRHN 639
                 |....:|:.....|..:||      ...::|..:|...:|:.|..::..||.|.||  ..
Human   333 GPASFNLSEYFRQFLLPQNECELH------DFRLSFSQLKWDNWIVAPHRYNPRYCKGDCP--RA 389

  Fly   640 PAHH-----HALLQSLIWQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECA 699
            ..|.     |.::|::|:::.....|||.|.|:|...|.:|.::.:.|  :....:.||...:|.
Human   390 VGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGS--IAYKEYEDMIATKCT 452

  Fly   700 C 700
            |
Human   453 C 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<438..518	CDD:480997	19/98 (19%)
		TGF_beta_maverick	598..700	CDD:381633	26/106 (25%)
GDF9	NP_005251.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..330		5/31 (16%)
		TGF_beta_GDF9	349..454	CDD:381673	29/115 (25%)