DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mav and GDF2

DIOPT Version :9

Sequence 1:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_057288.1	Gene:	GDF2 / 2658	HGNCID:	4217	Length:	429	Species:	Homo sapiens

Alignment Length:	257	Identity:	57/257 - (22%)
Similarity:	105/257 - (40%)	Gaps:	47/257 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 ETRT----------QWIEFDVTKAVRSWL----NKSHENLGIEIQCDK--CKSI------GARIL 518
            ||:|          .|...:|:.||:.|:    .||...|.:.::..:  |.::      |:|.|
Human   187 ETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNL 251

  Fly   519 SDFSPSTPPRSTASSDEHLNLMPVLNIIGHGTLNS-QQHGDADIHQIMLTNNRSDQYVHHRSNHD 582
            ..|...:...|:.:.:..|.|..:::......|.. .:.|..:..:   :::..|...|..:.
Human   252 PFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGE---SSHEEDTDGHVAAG-- 311

  Fly   583 STWRKDKWTNNCYKLHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRC---------PPRH 638
            ||..:.|.:...   ...|.:..|.|.|:.|....:|:.||.::|..|.|.|         |.:
Human   312 STLARRKRSAGA---GSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTK- 372

  Fly   639 NPAHHHALLQSLIWQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECAC 700
                 ||::|:|:..:...:..:.||.|:||..:.:|:.|:.....||.. :..|.|.||.|
Human   373 -----HAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYH-YEGMSVAECGC 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	11/43 (26%)
mav	NP_524626.1	TGF_beta	599..700	CDD:278448	30/109 (28%)
GDF2	NP_057288.1	TGFb_propeptide	76..257	CDD:279078	16/69 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..308		3/27 (11%)
		TGF_beta	326..428	CDD:278448	30/108 (28%)
		Interaction with ENG. /evidence=ECO:0000269\|PubMed:28564608	402..416		3/13 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810