DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mav and Bmp3

DIOPT Version :9

Sequence 1:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_058801.1	Gene:	Bmp3 / 25667	RGDID:	2212	Length:	468	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	98/445 - (22%)
Similarity:	145/445 - (32%)	Gaps:	156/445 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 HDKIDEANVRLMLLYSSSLATNFRRGPGSRKNKISQISGNDNIERHCNFGDVNLNQSNKNSSQQL 446
            |||:.|..:.|...||.|......|.|||:......:.|.:.:.        :...:...:.|:.
  Rat    53 HDKVSEHMLWLYDRYSGSNRAQATRTPGSQLPGPQPLRGGNTVR--------SFRAAAAGTLQRK 109

  Fly   447 TLKVYQLLSANRRRKITSRKIEF-------GNVGFQETR---------------TQW-------- 481
            .|..:.|.|..:...|.|..:.|       .:|...|::               :.|
  Rat   110 GLHTFNLTSLTKSENILSATLYFYIGELVNTSVNCPESQGCSHDSQRQHIQIDLSAWTLQSNQSQ 174

  Fly   482 ----IEFDVTKAVR---SWLNKSHENLGIEIQCDKCKSIGARILS-------------------- 519
                :..|..|..|   |||:|....|..:.:.|:...||..|.|
  Rat   175 LLGHLSVDTAKPYRDSMSWLSKDITQLLRKAKQDEEFLIGFNITSRAHELPKRMLLFPEPYILVY 239

  Fly   520 --------------------DFSPSTPPRSTASSDEHLN-----------LMPVLNIIGHGTLNS 553
                                ||:..|.||..:...|.|:           |:|:.|....|.  .
  Rat   240 ANDAAICEPESVVSSLQRHRDFTAGTVPRLDSHVREALSVERRKKRSTGILLPLQNNELPGA--E 302

  Fly   554 QQHGDADI----------------------------HQIMLTNNRSDQYVHHRSNHDSTWRKDKW 590
            .|:.:|.:                            ||...|....:|.:...       |:.:|
  Rat   303 YQYKEAGVWEERKPYKSLQTQPPEKSRSKKKQRKGPHQKGQTLQFDEQTLKKA-------RRKQW 360

  Fly   591 TNNCYKLHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCP---PRHNPAHHHALLQSLIW 652
            ..     .:.|.|..|.|.|..|...|:|:.||.|||.||.|.|.   |:.....:||.:||::
  Rat   361 IE-----PRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIV- 419

  Fly   653 QEDHKRA-------PRPCCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECAC 700
                 ||       |.|||.|.|:..|.||..|||.:..||:  :.:|.|..|||
  Rat   420 -----RAVGVVSGIPEPCCVPEKMSSLSILFFDENKNVVLKV--YPNMTVDSCAC 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	18/100 (18%)
mav	NP_524626.1	TGF_beta	599..700	CDD:278448	41/110 (37%)
Bmp3	NP_058801.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..53		98/445 (22%)
		TGFb_propeptide	46..>203	CDD:279078	31/157 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..93		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..349		3/32 (9%)
		TGF_beta	364..467	CDD:278448	41/110 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810