DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mav and Tgfb1

DIOPT Version :9

Sequence 1:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_035707.1	Gene:	Tgfb1 / 21803	MGIID:	98725	Length:	390	Species:	Mus musculus

Alignment Length:	379	Identity:	90/379 - (23%)
Similarity:	151/379 - (39%)	Gaps:	102/379 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 HRRSLKKINRLNQNPKKHQNYGDLLRGEQDTMNILLHFPLTNAQDANFHHDKIDEANVRLMLLYS 397
            :.:.:.::..:::|...::...|:      :.:|.:.|..::.::|......:..|.:||..|.|
Mouse   104 YAKEVTRVLMVDRNNAIYEKTKDI------SHSIYMFFNTSDIREAVPEPPLLSRAELRLQRLKS 162

  Fly   398 SSLATNFRRGPGSRKNKISQISGNDNIERHCNFGDVNLNQSNKNSSQQLTLKVYQLLSANRRRKI 462
            |                         :|:|                    :::||..|.|..|.:
Mouse   163 S-------------------------VEQH--------------------VELYQKYSNNSWRYL 182

  Fly   463 TSRKIEFGNVGFQETRT-QWIEFDVTKAVRSWLNKSHENLGIEIQCDKCKSIGARILSDFSPSTP 526
                   ||.....|.| :|:.||||..||.|||:..   ||:         |.|    ||...
Mouse   183 -------GNRLLTPTDTPEWLSFDVTGVVRQWLNQGD---GIQ---------GFR----FSAHC- 223

  Fly   527 PRSTASSDEHLNLMPVLNIIGHGTLNSQQHGD-ADIHQ-------IMLTNNRSDQYVHHRSNHDS 583
              |..|.|..|:    :.|.|   ::.::.|| ..||.       :|.|.....|:: |.|.|
Mouse   224 --SCDSKDNKLH----VEING---ISPKRRGDLGTIHDMNRPFLLLMATPLERAQHL-HSSRH-- 276

  Fly   584 TWRKDKWTNNCY-KLHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCPPRHNPAHHHALL 647
              |:...||.|: ...:.||..||.:.|:...|:::|.:||.:.|.:|.|.||...:....::.:
Mouse   277 --RRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKV 339

  Fly   648 QSLIWQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECACS 701
            .:|..|.:...:..|||.|..||.|.|::.   ...|.|:...|:|.|..|.||
Mouse   340 LALYNQHNPGASASPCCVPQALEPLPIVYY---VGRKPKVEQLSNMIVRSCKCS 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	21/64 (33%)
mav	NP_524626.1	TGF_beta	599..700	CDD:278448	30/100 (30%)
Tgfb1	NP_035707.1	TGFb_propeptide	30..261	CDD:366248	48/240 (20%)
		Straightjacket domain. /evidence=ECO:0000250\|UniProtKB:P07200	30..74
		Arm domain. /evidence=ECO:0000250\|UniProtKB:P07200	75..271		51/250 (20%)
		Bowtie tail. /evidence=ECO:0000250\|UniProtKB:P01137	226..252		8/32 (25%)
		Cell attachment site. /evidence=ECO:0000255	244..246		0/1 (0%)
		TGF_beta_TGFB1	292..390	CDD:381654	30/100 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1343
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810