DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mav and gdf9

DIOPT Version :9

Sequence 1:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	XP_002935305.1	Gene:	gdf9 / 100496740	XenbaseID:	XB-GENE-478149	Length:	421	Species:	Xenopus tropicalis

Alignment Length:	508	Identity:	103/508 - (20%)
Similarity:	178/508 - (35%)	Gaps:	159/508 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 TRLKHLVLKGLGIKKLPDMRKVNISQAEYSSKY--IEYLSRLRSNQEK--GNSYFNNFMGASFTR 311
            |.|..|.:.|.|:              |||..|  :..|.:..|.:.|  .|:...|.:...:.:
Frog    14 TWLLPLQIGGFGL--------------EYSEDYSLLPPLFKELSERPKWSDNAPGPNMVAIKYMK 64

  Fly   312 DLHFLSITTNGFNDISNKRLRHRRSLKKINRLNQNPKKHQNYGDLLRGEQDTMNILLHFPLTNAQ 376
            .|:.:|.|..||                 .||::||..:              .:.|..|.|..:
Frog    65 RLYKMSATKEGF-----------------PRLHKNPVYN--------------TVRLFTPRTECK 98

  Fly   377 --------------DANFHHDKID--EANVRLMLLYSSSLATNFRRGPGSRKNKISQISGNDNIE 425
                          |..|..|::.  |..::.:||||                 :|:...:.||.
Frog    99 PEREREINGGMQSLDLTFSVDRVSAVEQLLQSLLLYS-----------------VSKRFSSSNIT 146

  Fly   426 RHCNFGDVNLNQSNKNSSQQLTLKVYQLLSANRRRKITSRKIEFGNVGFQETRTQWIEFDVTKAV 490
            ..|:                |.:..|:|.|....|...|...:.      ..|.:|:|.|||..:
Frog   147 CTCS----------------LEILGYELQSTVCPRAPQSFHFQL------RKRQRWVEIDVTSIL 189

  Fly   491 RSWLNKSHEN--LGIEIQCDKCKSIGARILSDFSPSTPPRSTASSDEHLNLMPVLNIIGHGTLNS 553
            :.:::...:|  ||:...|.|...     ..||:.:.|.:.|.|.       |.|.:..:.|.|.
Frog   190 QPFISNKRQNIHLGLNFTCMKNNK-----HYDFATTGPFKMTRSP-------PSLLLYLNDTSNK 242

  Fly   554 QQHGDADIHQI--------------MLT----NNRSDQYVHHRSNHD-------------STWRK 587
            ..|... :|.|              :|.    |.:..|....|.|||             .|:..
Frog   243 AYHRRI-MHDIAEQPLYYPVGRIPSILADDEGNLKLQQMSRRRRNHDYEAILEENTTVVPHTFNF 306

  Fly   588 DKWTNNCYKLHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCP----PRH-NPAHHHALL 647
            .::.......|..|..::..::|..:...::||.|..:...||.|.||    .|: :|.  |.::
Frog   307 SEYLKQFVYSHNECELHRFRLSFSQLNWDKWILAPHRYSPDYCKGVCPRIVGHRYGSPV--HTIV 369

  Fly   648 QSLIWQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECAC 700
            |::|:::.....|||.|.||:...:.:|.::.::|  :....:.||...:|.|
Frog   370 QNIIYEKVDSSIPRPSCVPSEYRPMSVLTIEPDNS--IAYKEYQDMIATKCTC 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	15/65 (23%)
mav	NP_524626.1	TGF_beta	599..700	CDD:278448	26/105 (25%)
gdf9	XP_002935305.1	TGF_beta_GDF9	318..421	CDD:381673	27/107 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910