DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and SCH9

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_012075.1	Gene:	SCH9 / 856612	SGDID:	S000001248	Length:	824	Species:	Saccharomyces cerevisiae

Alignment Length:	841	Identity:	176/841 - (20%)
Similarity:	287/841 - (34%)	Gaps:	265/841 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 NSNASKTGS----PFCK------CASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWS 408
            |:|:|..|:    | ||      |||.     |:|         |..||.||.....|:||
Yeast    30 NNNSSTAGNDNGYP-CKLVSSGPCASS-----NNG---------ALFTNFTLQTATPTTAI---- 75

  Fly   409 APAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHA 473
                ::...:...:.|...:.::::|......:.|.|.:::|  .|.||.:..|   |....:|.
Yeast    76 ----SQDLYAMGTTGITSENALFQMKSMNNGISSVNNNNSNT--PTIITTSQEE---TNAGNVHG 131

  Fly   474 INSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLN-------------EVKTGQAEIVFT 525
            ....:.:...:..:..||  :.:..:.|:||.|:|    |             ::..|:.|:
Yeast   132 DTGGNSLQNSEDDNFSSS--STTKCLLSSTSSLSI----NQREAAAAAYGPDTDIPRGKLEV--- 187

  Fly   526 TESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVE--------LDAINKSAL 582
                   |:...|.|...:||:     :|         |.|..|...|        |.|||.:..
Yeast   188 -------TIIEARDLVTRSKDS-----QP---------YVVCTFESSEFISNGPESLGAINNNNN 231

  Fly   583 NTKETK----AHIVGLLENTEYGFQVRCKTNNGFGSYSNM-----------IYA-------QTLQ 625
            |....:    .||....|||......:...||...:.|.:           :|.       ..|.
Yeast   232 NNNNNQHNQNQHINNNNENTNPDAASQHHNNNSGWNGSQLPSIKEHLKKKPLYTHRSSSQLDQLN 296

  Fly   626 SVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVN 690
            |..||.|.                              ||...:....|:|.   |.:.:|:.:.
Yeast   297 SCSSVTDP------------------------------SKRSSNSSSGSSNG---PKNDSSHPIW 328

  Fly   691 SMDTTPIVKKLHLNVTTPLF---------GNSRSYVDPHTYEDPNQ---------AIREFA---- 733
            ...||..|...|..:...::         |..|.|...|.....:|         .|.|..
Yeast   329 HHKTTFDVLGSHSELDISVYDAAHDHMFLGQVRLYPMIHNLAHASQHQWHSLKPRVIDEVVSGDI 393

  Fly   734 -----------REIDANYITIEAIIGGGEFGDVCRGRLK----IPPNFVQDIDVAIKTLKPGSSE 783
                       |........:..::|.|.||.|.:.:.|    |....|....|.:|..:...:.
Yeast   394 LIKWTYKQTKKRHYGPQDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHTI 458

  Fly   784 KARCDFLTEAS-----IMG---QFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKF 840
            ..|...:|.||     |:|   .|..|..:||            :|:||..|.|...|: .:|:|
Yeast   459 GERNILVTTASKSSPFIVGLKFSFQTPTDLYL------------VTDYMSGGELFWHLQ-KEGRF 510

  Fly   841 QTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSR-EIENASDAY--TT 902
            ...:....:..:...:.:|.|.:.|:|||...|:|::|.....:.|||||: ::::.::.:  ||
Yeast   511 SEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADLKDRTNTFCGTT 575

  Fly   903 RGGKIPVRWTAPEAIAFRK-FTSASDVWSYGVVLWEVMSYGERPYWNWSNQ-------------- 952
                   .:.|||.:.... :|...|.||.||:::| |..|..|::..:||
Yeast   576 -------EYLAPELLLDETGYTKMVDFWSLGVLIFE-MCCGWSPFFAENNQKMYQKIAFGKVKFP 632

  Fly   953 -DVI----KSIEKG-------YRLPAPMDCPE-ALYQLMLDC-WQ--KQRTHRPTF-ASIVSTLD 1000
             ||:    :|..||       :||.|..|..| ..:....|. |:  ||:...|.| ..:||..|
Yeast   633 RDVLSQEGRSFVKGLLNRNPKHRLGAIDDGRELRAHPFFADIDWEALKQKKIPPPFKPHLVSETD 697

  Fly  1001 NLARQP-------------QSLLTTRP-SPESDGNHILDGQRGQNIFISTDLWLEHIKMSR 1047
            .....|             |.::|..| ||      .:..:.....|:......||:..:|
Yeast   698 TSNFDPEFTTASTSYMNKHQPMMTATPLSP------AMQAKFAGFTFVDESAIDEHVNNNR 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	19/88 (22%)
		FN3	536..623	CDD:238020	23/116 (20%)
		EphA2_TM	644..736	CDD:291255	18/124 (15%)
		PTKc_EphR	736..1002	CDD:270629	78/312 (25%)
		Pkinase_Tyr	741..999	CDD:285015	77/304 (25%)
		SAM_1	1033..1092	CDD:278937	4/15 (27%)
		SAM	1039..1092	CDD:197735	3/9 (33%)
SCH9	NP_012075.1	YPK1_N_like	181..407	CDD:212165	49/282 (17%)
SCH9	NP_012075.1	STKc_Sck1_like	418..738	CDD:270738	84/346 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000