DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT1G79620

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001321899.1	Gene:	AT1G79620 / 844301	AraportID:	AT1G79620	Length:	997	Species:	Arabidopsis thaliana

Alignment Length:	679	Identity:	164/679 - (24%)
Similarity:	268/679 - (39%)	Gaps:	154/679 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 KNESFSSETNSKIYHSDIVY--KIKCNICSPNVVYNPSTDTFNETKITLTNLE--PVTTYTVQIH 472
            ::...||.|.|..|.:.::|  ....|:.| |.:|.|..:.     ::...||  ||.|
plant   377 QDNDISSVTLSSGYTNTLMYIASFFLNVQS-NCLYQPIKEA-----LSCCRLEGNPVCT------ 429

  Fly   473 AINSVSHIN-------EFKRHSNESSLVAVSDIVFSNTSLLN-----IPLDLNEVKTGQAEIVFT 525
              .::|:.|       :.||             ::| |||.|     .||| .:|.....|..:.
plant   430 --TALSNTNYCQIQQQQVKR-------------IYS-TSLANCGGKSCPLD-QKVSPQSCECAYP 477

  Fly   526 TESVLLSTVFNLRILAITNKDADLE---WDK----PVQSDFPLEFYEVRWFPKVELDAINKSALN 583
            .|..|.......|.|:..|....||   |.|    |........|:....:.:::|.........
plant   478 YEGTLYFRGPMFRDLSNVNTYHSLEMSLWVKLGLTPGSVSLQNPFFNNDDYLQIQLALFPPMGKY 542

  Fly   584 TKETKAHIVGL-LENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTG 647
            ...|:...:|. |.|..|      |....||.|..:....|..:.|:.:  |:..|.:.| |:||
plant   543 FNRTEVQRIGFDLSNQTY------KPPPLFGPYYFIASPYTFPADGNGH--SLSSRMVTG-IITG 598

  Fly   648 VLFLVIFIIAT-VYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFG 711
            ...||:.::|. :|.|..|      :::...:.|...:.|...:..|:.          ..|...
plant   599 CSALVLCLVALGIYAMWQK------RRAEQAIGLSRPFVSWASSGKDSG----------GAPQLK 647

  Fly   712 NSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDID-VAIK 775
            .:|.:    :||:        .::|..|: ::.:.:|.|.:|.|.:|.|       ||.. ||||
plant   648 GARWF----SYEE--------LKKITNNF-SVSSELGYGGYGKVYKGML-------QDGHMVAIK 692

  Fly   776 TLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKF 840
            ..:.||:: ...:|.||..::.:..|.|::.|.|........:::.|||.||||...|....|
plant   693 RAQQGSTQ-GGLEFKTEIELLSRVHHKNLVGLVGFCFEQGEQILVYEYMSNGSLKDSLTGRSG-- 754

  Fly   841 QTLQLIVMLR---GIASGMSY---LSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDA 899
            .||.....||   |.|.|::|   |:|...:|||:.:.|:|::..|..|:||||||:.:.:.:..
plant   755 ITLDWKRRLRVALGSARGLAYLHELADPPIIHRDVKSTNILLDENLTAKVADFGLSKLVSDCTKG 819

  Fly   900 YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKG--- 961
            :.:...|..:.:..||....:|.|..|||:|:|||:.|::: .::|            ||||
plant   820 HVSTQVKGTLGYLDPEYYTTQKLTEKSDVYSFGVVMMELIT-AKQP------------IEKGKYI 871

  Fly   962 ---------------YRLPAPMD--------CPE--ALYQLMLDCWQKQRTHRPTFASIVSTLD- 1000
                           |.|...||        .||  ...:|.|.|..:....|||.:.:|..::
plant   872 VREIKLVMNKSDDDFYGLRDKMDRSLRDVGTLPELGRYMELALKCVDETADERPTMSEVVKEIEI 936

  Fly  1001 ---NLARQPQSLLTTRPSPESDGNHILDG 1026
               |......|..:...|....|..:|.|
plant   937 IIQNSGASSSSSASASSSATDFGEKLLYG 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	16/67 (24%)
		FN3	536..623	CDD:238020	19/94 (20%)
		EphA2_TM	644..736	CDD:291255	16/92 (17%)
		PTKc_EphR	736..1002	CDD:270629	86/304 (28%)
		Pkinase_Tyr	741..999	CDD:285015	84/292 (29%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G79620	NP_001321899.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960