DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT1G73660

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_177507.1	Gene:	AT1G73660 / 843701	AraportID:	AT1G73660	Length:	1030	Species:	Arabidopsis thaliana

Alignment Length:	744	Identity:	181/744 - (24%)
Similarity:	279/744 - (37%)	Gaps:	142/744 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 PCPPNSNASKTGSPFCKCASGFYRHPNDGRH--MPCYSPPAA--PTNLTLLFVDQTSAIISWSAP 410
            ||........|||.  ..|..|.: .:|||.  :.....|..  |.:...|.:|...:..| ::|
plant   343 PCRIVKGQQYTGSE--DVAMNFIK-ADDGREYIVDLMGDPGTLIPADAAGLQIDYDESAYS-ASP 403

  Fly   411 AKNESF-----------SSETNSKIYHSDIVYKIKCN------------ICSPNVVYNPSTDTFN 452
            ..|:|.           |.|.|::....:.....|.:            |..||:   ...|..|
plant   404 GDNDSIHVASSSNGIESSYEENTEFRTGEHRSSTKSSGERNQSGGGGDLIVHPNI---SREDVKN 465

  Fly   453 ETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVA----VSDI--------------- 498
            :.|:     |......:....|:|.:|:.........||..|    |.|:
plant   466 QKKV-----EKAPFQNLSSRPIHSFTHMRSPSWTEGVSSPAAQRMKVKDVSQYMIDAAKENPRLA 525

  Fly   499 -----VFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSD 558
                 |...:.::..|...:||...|.|.  |.||...:.....|     .||.:...:...|:.
plant   526 QKLHDVLLESGVVAPPNLFSEVYPQQLEA--TVESKNSTEAKKER-----GKDLETTQEGRHQNG 583

  Fly   559 F-PLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLE-------NTEYGFQVRCKTNNGFGSY 615
            | |:.|...  .|:|:    :|:..:.:.....:|...:       :|||...|...........
plant   584 FGPVRFLPP--LPRVQ----SKTNAHDQRDNGKVVSQSDSSHSEASSTEYARTVPAAVAAAAVVA 642

  Fly   616 SNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKH-----QDDLDKKST 675
            |:|:.|...:|..|   ||..|...|.|..|.....|:...|.|    |:.     ..|.|..|.
plant   643 SSMVAAAAAKSANS---DSSPIELPAAAAATATAAAVVATAAAV----SRQLELGSNSDGDDGSG 700

  Fly   676 NHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANY 740
            .|.|.....:::..||...         .::....||..|..|.....|         .||....
plant   701 GHEPQGSGDSNHGPNSGGE---------RISDKSIGNESSKSDCDDVSD---------CEILWEE 747

  Fly   741 ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKT-LKPGSSEKARCDFLTEASIMGQFDHPNV 804
            ||:...||.|.:|:|.||..       ...:||:|. |....:.:|..:|.:|..||.:..|||:
plant   748 ITVGERIGLGSYGEVYRGDW-------HGTEVAVKKFLDQDLTGEALEEFRSEVRIMKKLRHPNI 805

  Fly   805 IYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMN--YVHR 867
            :...|.|||...:.|:||::..|||...:...:.:....:.:.|....|.||:||...|  .|||
plant   806 VLFMGAVTRPPNLSIVTEFLPRGSLYRLIHRPNNQLDERRRLRMALDAARGMNYLHSCNPMIVHR 870

  Fly   868 DLAARNVLVNAQLICKIADFGLSR-----EIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASD 927
            ||.:.|:||:...:.|:.||||||     .:.:.|.|.|       ..|.|||.:.........|
plant   871 DLKSPNLLVDKNWVVKVCDFGLSRMKHSTYLSSKSTAGT-------AEWMAPEVLRNEPADEKCD 928

  Fly   928 VWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGY---RLPAPMDCPEALYQLMLDCWQKQRTHR 989
            |:||||:|||:.:. ::|:...:...|:.::  |:   ||..|.....|:..|:..|||.....|
plant   929 VYSYGVILWELFTL-QQPWGKMNPMQVVGAV--GFQHRRLDIPDFVDPAIADLISKCWQTDSKLR 990

  Fly   990 PTFASIVSTLDNLARQPQSLLTTRPSPES 1018
            |:||.|:::|..|.:........||.|.|
plant   991 PSFAEIMASLKRLQKPVTGSNIPRPVPSS 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	20/113 (18%)
		FN3	536..623	CDD:238020	18/94 (19%)
		EphA2_TM	644..736	CDD:291255	17/96 (18%)
		PTKc_EphR	736..1002	CDD:270629	87/276 (32%)
		Pkinase_Tyr	741..999	CDD:285015	85/268 (32%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G73660	NP_177507.1	EDR1	179..383	CDD:316869	11/42 (26%)
AT1G73660	NP_177507.1	STKc_MAP3K-like	754..1000	CDD:270901	83/262 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910