DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and RPK1

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_177087.1	Gene:	RPK1 / 843258	AraportID:	AT1G69270	Length:	540	Species:	Arabidopsis thaliana

Alignment Length:	652	Identity:	133/652 - (20%)
Similarity:	235/652 - (36%)	Gaps:	185/652 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 SFS----SETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAIN 475
            |||    :|:...::....:.|:|.:...||.|.:.....                        :
plant    17 SFSRKLLTESGGGLHDEAALLKLKSSFLDPNGVLSSWVSD------------------------S 57

  Fly   476 SVSHINEFKRHSNESSLVAVSDIV-----FSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVF 535
            |.:|.:.:....|..|.| ||.|:     ...:.:|::| ||:...:.:..:.... |.::..:.
plant    58 SSNHCSWYGVSCNSDSRV-VSLILRGCDELEGSGVLHLP-DLSSCSSSKRRLGGVI-SPVVGDLS 119

  Fly   536 NLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEY 600
            .:|:|:::..|        ::.:.|.|.:.:.                    |..|:.|..|...
plant   120 EIRVLSLSFND--------LRGEIPKEIWGLE--------------------KLEILDLKGNNFI 156

  Fly   601 GFQVRCKTNNGFGSYSNMIYAQTL-----QSVG--SVYDDS--------VQIRFIAGAIVTGVLF 650
            |         |.....|::..:.:     ..:|  |..|||        ::|..|..|.|. |..
plant   157 G---------GIRVVDNVVLRKLMSFEDEDEIGPSSADDDSPGKSGLYPIEIASIVSASVI-VFV 211

  Fly   651 LVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRS 715
            |::.:|..:|..:.|.                       ||......:|::            :.
plant   212 LLVLVILFIYTRKWKR-----------------------NSQVQVDEIKEI------------KV 241

  Fly   716 YVD---PHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTL 777
            :||   |.|||...:|         ..|.:....||.|.||...:..:. |.|.     .|:|.|
plant   242 FVDIGIPLTYEIIVRA---------TGYFSNSNCIGHGGFGSTYKAEVS-PTNV-----FAVKRL 291

  Fly   778 KPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDG---K 839
            ..|..:..: .|..|.|.:....|||::.|.|.......:.:|..|:..|:|..|::....   :
plant   292 SVGRFQGDQ-QFHAEISALEMVRHPNLVMLIGYHASETEMFLIYNYLSGGNLQDFIKERSKAAIE 355

  Fly   840 FQTLQLIVMLRGIASGMSYLSDM---NYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYT 901
            ::.|..|.:  .:|..:|||.:.   ..:|||:...|:|::......::|||||: :...|.::.
plant   356 WKVLHKIAL--DVARALSYLHEQCSPKVLHRDIKPSNILLDNNYNAYLSDFGLSK-LLGTSQSHV 417

  Fly   902 TRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPA 966
            |.|......:.|||.....:.:..:||:|||:||.|::| .:|     :......|.|.|:.:.:
plant   418 TTGVAGTFGYVAPEYAMTCRVSEKADVYSYGIVLLELIS-DKR-----ALDPSFSSHENGFNIVS 476

  Fly   967 ------------------------PMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQ 1007
                                    |.|..|.|: |.|.|.....:.|||....|..|..:  ||.
plant   477 WAHMMLSQGKAKEVFTTGLWETGPPDDLVEVLH-LALKCTVDSLSIRPTMKQAVRLLKRI--QPS 538

  Fly  1008 SL 1009
            .|
plant   539 RL 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	9/64 (14%)
		FN3	536..623	CDD:238020	12/86 (14%)
		EphA2_TM	644..736	CDD:291255	16/94 (17%)
		PTKc_EphR	736..1002	CDD:270629	72/295 (24%)
		Pkinase_Tyr	741..999	CDD:285015	70/287 (24%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
RPK1	NP_177087.1	PKc_like	267..535	CDD:304357	71/284 (25%)
RPK1	NP_177087.1	Pkinase	267..530	CDD:278497	69/279 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050