DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and AT1G68400

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_177007.1	Gene:	AT1G68400 / 843169	AraportID:	AT1G68400	Length:	670	Species:	Arabidopsis thaliana

Alignment Length:	729	Identity:	152/729 - (20%)
Similarity:	258/729 - (35%)	Gaps:	212/729 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   396 LFVDQTSAIISWSA---PAKNESFSSETN--SKIYHSDI----------------VYKIKCNICS 439
            |..|.|..:.||:.   |.:....|...|  :::...||                |..:|.|..|
plant    40 LTADSTGKLNSWNTTTNPCQWTGVSCNRNRVTRLVLEDINLTGSISSLTSLTSLRVLSLKHNNLS 104

  Fly   440 ---PN-----------VVYNPSTDTFNETKITLTNLEPV----TTYTVQIHA-INSVSHINEFKR 485
               ||           :..|..:..|..:..:||.|..:    ..::.||.. :..::|:...:.
plant   105 GPIPNLSNLTALKLLFLSNNQFSGNFPTSITSLTRLYRLDLSFNNFSGQIPPDLTDLTHLLTLRL 169

  Fly   486 HSNESS----LVAVSDIVFSNTSLLN----IPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAI 542
            .||..|    .:.:||:...|.|..|    ||..|::.    .|.|||....|...    .:|..
plant   170 ESNRFSGQIPNINLSDLQDFNVSGNNFNGQIPNSLSQF----PESVFTQNPSLCGA----PLLKC 226

  Fly   543 TNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCK 607
            |...:|     |.:...|              |....|.||..||       :.::........|
plant   227 TKLSSD-----PTKPGRP--------------DEAKASPLNKPET-------VPSSPTSIHGGDK 265

  Fly   608 TNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFM--------RS 664
            :||          ...:.::..:            ||:.|...::.|:...:|:.        :.
plant   266 SNN----------TSRISTISLI------------AIILGDFIILSFVSLLLYYCFWRQYAVNKK 308

  Fly   665 KHQDDLDKK----STNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDP 725
            ||...|:.:    |:|  |.|....:|...:.......|.:       .|..:|.:    ..||.
plant   309 KHSKILEGEKIVYSSN--PYPTSTQNNNNQNQQVGDKGKMV-------FFEGTRRF----ELEDL 360

  Fly   726 NQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFL 790
            .:|..|              ::|.|.||...:..|:      ...:||:|.||...:...:.:|.
plant   361 LRASAE--------------MLGKGGFGTAYKAVLE------DGNEVAVKRLKDAVTVAGKKEFE 405

  Fly   791 TEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQT-LQLIVMLR---G 851
            .:..::|:..|.|::.|:.........:::.:||.||||...|..|.|..:| |.....|:   |
plant   406 QQMEVLGRLRHTNLVSLKAYYFAREEKLLVYDYMPNGSLFWLLHGNRGPGRTPLDWTTRLKIAAG 470

  Fly   852 IASGMSYL----SDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWT 912
            .|.|::::    ..:...|.|:.:.|||::.....:::|||||  |...|.......|     :.
plant   471 AARGLAFIHGSCKTLKLTHGDIKSTNVLLDRSGNARVSDFGLS--IFAPSQTVAKSNG-----YR 528

  Fly   913 APEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPE----- 972
            |||.|..||.|..|||:|:||:|.|::: |:.|          ..:|.|:...| :|.|.
plant   529 APELIDGRKHTQKSDVYSFGVLLLEILT-GKCP----------NMVETGHSGGA-VDLPRWVQSV 581

  Fly   973 -------------------------ALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTT 1012
                                     .|.|:.:.|......|||....:|..::::...     .:
plant   582 VREEWTAEVFDLELMRYKDIEEEMVGLLQIAMACTAVAADHRPKMGHVVKLIEDIRGG-----GS 641

  Fly  1013 RPSPESDG-NHILD 1025
            ..||.:|| |..:|
plant   642 EASPCNDGINSAVD 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	23/119 (19%)
		FN3	536..623	CDD:238020	14/86 (16%)
		EphA2_TM	644..736	CDD:291255	19/103 (18%)
		PTKc_EphR	736..1002	CDD:270629	72/303 (24%)
		Pkinase_Tyr	741..999	CDD:285015	72/295 (24%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G68400	NP_177007.1	LRRNT_2	30..66	CDD:285463	7/25 (28%)
		leucine-rich repeat	94..115	CDD:275380	6/20 (30%)
		leucine-rich repeat	116..139	CDD:275380	3/22 (14%)
		leucine-rich repeat	140..163	CDD:275380	3/22 (14%)
		leucine-rich repeat	164..185	CDD:275380	3/20 (15%)
		leucine-rich repeat	186..205	CDD:275380	5/18 (28%)
		S_TKc	366..>560	CDD:214567	60/221 (27%)
		STKc_IRAK	368..636	CDD:270968	72/292 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050