DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT1G67510

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_176918.1	Gene:	AT1G67510 / 843072	AraportID:	AT1G67510	Length:	719	Species:	Arabidopsis thaliana

Alignment Length:	755	Identity:	154/755 - (20%)
Similarity:	272/755 - (36%)	Gaps:	212/755 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 NDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKN--ESFSSETNSKIYHSDIVYKIKCNIC 438
            ||....||:....:..|::   ...||.::..|...|:  ....||..|      ::|..:.|:.
plant    49 NDNDTDPCHWSGISCMNIS---DSSTSRVVGISLAGKHLRGYIPSELGS------LIYLRRLNLH 104

  Fly   439 SPNVVYNPSTDTFNETKI----------------------TLTNLEPVTTYTVQIHAINSVS--- 478
            :..:..:..|..||.|.:                      .|.||:         .::||:|
plant   105 NNELYGSIPTQLFNATSLHSIFLYGNNLSGTLPPSICKLPKLQNLD---------LSMNSLSGTL 160

  Fly   479 --HINEFKR------HSNESSLVAVSDIVFSNTSLL-----------NIPLDLNEVK--TGQAEI 522
              .:|:.|:      .:|..|.....||....|:|.           .||.|:.|:|  :|...:
plant   161 SPDLNKCKQLQRLILSANNFSGEIPGDIWPELTNLAQLDLSANEFSGEIPKDIGELKSLSGTLNL 225

  Fly   523 VFT-TESVLLSTVFNLRI-LAITNKDADLEWDKPVQSDF----PLEFYEVRWFPKVELDAINKSA 581
            .|. ....:.:::.||.: :::..::.|...:.|....|    |..|..   .||:....:.|:.
plant   226 SFNHLSGQIPNSLGNLPVTVSLDLRNNDFSGEIPQSGSFSNQGPTAFLN---NPKLCGFPLQKTC 287

  Fly   582 LNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVT 646
               |:|..:..|..::.|.....|...:.|.         ..|.||.    |:..:.||.
plant   288 ---KDTDENSPGTRKSPENNADSRRGLSTGL---------IVLISVA----DAASVAFIG----- 331

  Fly   647 GVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFG 711
                     :..||....|...:.....|.:..|    ....|.                    |
plant   332 ---------LVLVYLYWKKKDSEGGCSCTGNAKL----GGGSVK--------------------G 363

  Fly   712 NSRSYVDPHTYEDPNQA-----------------IREFAREIDANYITIEAIIGGGEFGDVCRGR 759
            .|...:.....||.::|                 .:.|:.|:|........::|....|.|.:..
plant   364 KSCCCITGFPKEDDSEAEGNERGEGKGDGELVAIDKGFSFELDELLRASAYVLGKSGLGIVYKVV 428

  Fly   760 LKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYM 824
            |.      ..:.||::.|..|..::.: :|:||...||:..||||:.|:......:..::|::::
plant   429 LG------NGVPVAVRRLGEGGEQRYK-EFVTEVQAMGKVKHPNVVKLRAYYWAPDEKLLISDFV 486

  Fly   825 ENGSLDTFLRVNDGK------FQTLQLIVMLRGIASGMSYL---SDMNYVHRDLAARNVLVNAQL 880
            .||||...||..:|:      :.|  .|.:.:|.|.|::||   |....||.|:...|:|:::..
plant   487 NNGSLADALRGRNGQPSPSLTWST--RIKIAKGAARGLAYLHECSPRKLVHGDVKPSNILLDSSF 549

  Fly   881 ICKIADFGLSR------------EIENASDAYTTRGGKIPVR----------WTAPEA-IAFRKF 922
            ...|:||||:|            |..::|.|....||.:|..          :.|||| :...:.
plant   550 TPYISDFGLTRLITITAASASSNEPSSSSAAGGFLGGALPYTSIKPSDRSNGYKAPEARLPGGRP 614

  Fly   923 TSASDVWSYGVVLWEVM---SYGERPYWNWSNQ-------DVIKSIEKGYRLPAPM-DCPE---- 972
            |...||:|:||||.|::   |....|..:.|..       |::|.:.||:....|: |..:
plant   615 TQKWDVYSFGVVLMELLTGKSPDSSPLSSSSTSTVVVEVPDLVKWVRKGFEEETPLSDMVDPMLL 679

  Fly   973 ----------ALYQLMLDCWQKQRTHRPTFASIVSTLDNL 1002
                      :::.|.|.|.:.....||...::...:|.:
plant   680 QEVHAKQQVLSVFHLALACTEGDPEVRPRMKNVSENIDKI 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	17/112 (15%)
		FN3	536..623	CDD:238020	16/91 (18%)
		EphA2_TM	644..736	CDD:291255	12/108 (11%)
		PTKc_EphR	736..1002	CDD:270629	80/322 (25%)
		Pkinase_Tyr	741..999	CDD:285015	78/314 (25%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G67510	NP_176918.1	LRRNT_2	23..63	CDD:369783	4/13 (31%)
		PLN00113	<70..717	CDD:215061	148/727 (20%)
		leucine-rich repeat	98..121	CDD:275380	4/22 (18%)
		leucine-rich repeat	122..145	CDD:275380	0/22 (0%)
		leucine-rich repeat	146..169	CDD:275380	7/31 (23%)
		leucine-rich repeat	170..194	CDD:275380	4/23 (17%)
		leucine-rich repeat	195..218	CDD:275380	5/22 (23%)
		leucine-rich repeat	219..243	CDD:275380	4/23 (17%)
		leucine-rich repeat	244..266	CDD:275380	3/21 (14%)
		STKc_IRAK	416..719	CDD:270968	79/311 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050