DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and AT1G64210

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_176603.1	Gene:	AT1G64210 / 842726	AraportID:	AT1G64210	Length:	587	Species:	Arabidopsis thaliana

Alignment Length:	689	Identity:	135/689 - (19%)
Similarity:	258/689 - (37%)	Gaps:	194/689 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 NLTLLFVDQTSAIISWSAPAKNESFSSETNSKIY---HSDIVYK---IKCN--------ICSPNV 442
            :|.|.||..:|..:.....|.....||..:|:::   .||:.:.   :.||        :..|.|
plant     9 SLILCFVLISSQTLEDDKKALLHFLSSFNSSRLHWNQSSDVCHSWTGVTCNENGDRIVSVRLPAV 73

  Fly   443 VYNPSTDTFNETKIT-------------------LTNLEPVTTYTVQIHAINSVSHINEFKRHSN 488
            .:|.....|..::::                   .|||:             |::|:  :.:|::
plant    74 GFNGLIPPFTISRLSSLKFLSLRKNHFTGDFPSDFTNLK-------------SLTHL--YLQHNH 123

  Fly   489 ESS-LVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWD 552
            .|. |:|    :||....|.: |||:  ..|....:.|:    ||.:.:|::|.:.|.....|
plant   124 LSGPLLA----IFSELKNLKV-LDLS--NNGFNGSIPTS----LSGLTSLQVLNLANNSFSGE-- 175

  Fly   553 KPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNG------ 611
                            .|.:.|..:  |.:|....|  ::|.:..:...||....:.|.
plant   176 ----------------IPNLHLPKL--SQINLSNNK--LIGTIPKSLQRFQSSAFSGNNLTERKK 220

  Fly   612 -----FGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLD 671
                 || .|.:.:...|.:.             ....|:|:.|::|     ..|.:::....|.
plant   221 QRKTPFG-LSQLAFLLILSAA-------------CVLCVSGLSFIMI-----TCFGKTRISGKLR 266

  Fly   672 KKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREI 736
            |:.::. | |.::.|.:.|:.:...|:          .||.                 |....::
plant   267 KRDSSS-P-PGNWTSRDDNTEEGGKII----------FFGG-----------------RNHLFDL 302

  Fly   737 DANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDID-VAIKTLKPGSSEKARCDFLTEASIMGQFD 800
            |....:...::|.|.||...:..:       :|:. |.:|.||  .....|.:|..:..|:|...
plant   303 DDLLSSSAEVLGKGAFGTTYKVTM-------EDMSTVVVKRLK--EVVVGRREFEQQMEIIGMIR 358

  Fly   801 HPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQL-----IVMLRGIASGMSYLS 860
            |.||..|:......:..:.:..|..:|||...|..|.|::..:.|     :.:..|.|.|::.:.
plant   359 HENVAELKAYYYSKDDKLAVYSYYNHGSLFEILHGNRGRYHRVPLDWDARLRIATGAARGLAKIH 423

  Fly   861 DMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSA 925
            :..::|.::.:.|:.:::|....|.|.||:..:.:.........|     :.|||....|:.|..
plant   424 EGKFIHGNIKSSNIFLDSQCYGCIGDVGLTTIMRSLPQTTCLTSG-----YHAPEITDTRRSTQF 483

  Fly   926 SDVWSYGVVLWEVMSYGERPY-----------------W-------NWSNQ--DV-IKSIEKGYR 963
            |||:|:||||.|::: |:.|.                 |       .|:.:  |: |.|...|:.
plant   484 SDVYSFGVVLLELLT-GKSPVSQAELVPTGGENMDLASWIRSVVAKEWTGEVFDMEILSQSGGFE 547

  Fly   964 LPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNL 1002
                .:..|.| |:.|.|...::..||..|.::..::::
plant   548 ----EEMVEML-QIGLACVALKQQERPHIAQVLKLIEDI 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	20/116 (17%)
		FN3	536..623	CDD:238020	16/97 (16%)
		EphA2_TM	644..736	CDD:291255	15/91 (16%)
		PTKc_EphR	736..1002	CDD:270629	67/298 (22%)
		Pkinase_Tyr	741..999	CDD:285015	66/290 (23%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G64210	NP_176603.1	LRRNT_2	22..59	CDD:285463	6/36 (17%)
		LRR_8	73..124	CDD:290566	9/65 (14%)
		LRR_RI	88..257	CDD:238064	40/235 (17%)
		leucine-rich repeat	90..113	CDD:275380	3/35 (9%)
		LRR_8	112..172	CDD:290566	19/85 (22%)
		leucine-rich repeat	114..137	CDD:275380	7/28 (25%)
		leucine-rich repeat	138..161	CDD:275380	8/29 (28%)
		leucine-rich repeat	162..183	CDD:275380	6/38 (16%)
		PKc_like	313..581	CDD:304357	66/287 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050