DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT1G56140

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_564709.2	Gene:	AT1G56140 / 842066	AraportID:	AT1G56140	Length:	1033	Species:	Arabidopsis thaliana

Alignment Length:	952	Identity:	199/952 - (20%)
Similarity:	346/952 - (36%)	Gaps:	290/952 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 DVDINTEVKSIAVNKKGVYFAFRDQ-GACISVLAVKVYYITCPAVT----ENFAHFNETPTGREI 280
            ::.:.|:::.::::......:..|: |.|..:..:   ||....::    .:||:
plant   165 EIGLLTDLRLLSISSNNFSGSIPDEIGRCTKLQQI---YIDSSGLSGGLPVSFAN---------- 216

  Fly   281 TIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTG----GCRCKAGYEPNYTNKT-CTECPLGTF 340
             ::|.:.....|.....:.|.::    |.||.||.    |.........:::|.| .||..||..
plant   217 -LVELEQAWIADMELTGQIPDFI----GDWTKLTTLRILGTGLSGPIPASFSNLTSLTELRLGDI 276

  Fly   341 KSPEVTKCTPCPPNSNASKTGSPFCKCASGF----YRHPNDGRHMPC----YSP----------- 386
            .            |.|:|   ..|.|.....    .|:.|....:|.    ||.
plant   277 S------------NGNSS---LEFIKDMKSLSILVLRNNNLTGTIPSNIGEYSSLRQLDLSFNKL 326

  Fly   387 ----PAAPTN---LTLLFVDQTSAIISWSAPA-KNESFSSETNSKIYHSDIVYKIKCNICSPNVV 443
                ||:..|   ||.||:...:  ::.|.|. |.:|.|   |..:.::|:...:...:..||:.
plant   327 HGTIPASLFNLRQLTHLFLGNNT--LNGSLPTQKGQSLS---NVDVSYNDLSGSLPSWVSLPNLN 386

  Fly   444 YNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSH----------INEFKRHSNESSLVAVSDI 498
            .|...:.|     ||..|:     ...:..:|.:..          .::|..:.....:.:|::.
plant   387 LNLVANNF-----TLEGLD-----NRVLSGLNCLQKNFPCNRGKGIYSDFSINCGGPEIRSVTEA 441

  Fly   499 VF----------------------SNTSLLNIPLDLNEVKTGQAEIVFTTESVLLS----TVFNL 537
            ||                      |:..|.....:...:.|.|::.|.|.:|.|..    :..:|
plant   442 VFEREDEDLGPASFVVSAGQRWAASSVGLFAGSSNNIYISTSQSQFVNTLDSELFQSARLSASSL 506

  Fly   538 RI--LAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNT------KETKAHIVGL 594
            |.  |.:.|....:          .|:|.|::         |..|..||      :....::.|.
plant   507 RYYGLGLENGGYTV----------TLQFAEIQ---------ILGSTSNTWRGLGRRRFDIYVQGR 552

  Fly   595 LENTEYGFQVR--------------CKTN------------NGFGSYSNMI---YAQTLQSVGSV 630
            |  .|..|.||              .|.|            .|.|:....|   |...:.:||:.
plant   553 L--VEKDFDVRRTAGDSTVRAVQREYKANVSQNHLEIHLFWAGKGTCCIPIQGAYGPLISAVGAT 615

  Fly   631 YDDSVQI--------RFIAGAIVTGVLF----------LVIFIIATVYFMRSKHQDDLDKKSTNH 677
            .|.:..:        :.:.|.|| ||:.          :|||||..   .|.::.||
plant   616 PDFTPTVGNRPPSKGKSMTGTIV-GVIVGVGLLSIISGVVIFIIRK---RRKRYTDD-------- 668

  Fly   678 LPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYIT 742
                     .|:.|||..|..                     .||.:...|.::|.   .:|.
plant   669 ---------EEILSMDVKPYT---------------------FTYSELKSATQDFD---PSNK-- 698

  Fly   743 IEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYL 807
                :|.|.||.|.:|:|.      ...:||:|.|..| |.:.:..|:.|...:....|.|::.|
plant   699 ----LGEGGFGPVYKGKLN------DGREVAVKLLSVG-SRQGKGQFVAEIVAISAVQHRNLVKL 752

  Fly   808 QGVVTRSNPVMIITEYMENGSLDTFLRVNDGKF--QTLQLIVMLR-----GIASGMSYLSD---M 862
            .|........:::.||:.|||||..|      |  :||.|....|     |:|.|:.||.:   :
plant   753 YGCCYEGEHRLLVYEYLPNGSLDQAL------FGEKTLHLDWSTRYEICLGVARGLVYLHEEARL 811

  Fly   863 NYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTR-GGKIPVRWTAPEAIAFRKFTSAS 926
            ..||||:.|.|:|::::|:.|::||||::..::.....:|| .|.|  .:.|||.......|..:
plant   812 RIVHRDVKASNILLDSKLVPKVSDFGLAKLYDDKKTHISTRVAGTI--GYLAPEYAMRGHLTEKT 874

  Fly   927 DVWSYGVVLWEVMS---------YGERPY---WNWSNQDVIKSIEK-GYRLPA-PMDCPEALYQL 977
            ||:::|||..|::|         ..|:.|   |.|:..:..:.:|. .::|.. .|:..:.:..:
plant   875 DVYAFGVVALELVSGRPNSDENLEDEKRYLLEWAWNLHEKGREVELIDHQLTEFNMEEGKRMIGI 939

  Fly   978 MLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESD 1019
            .|.|.|.....||..:.:|:.|.....  .|.:|::|...:|
plant   940 ALLCTQTSHALRPPMSRVVAMLSGDVE--VSDVTSKPGYLTD 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	5/39 (13%)
		FN3	387..476	CDD:238020	21/92 (23%)
		FN3	536..623	CDD:238020	23/123 (19%)
		EphA2_TM	644..736	CDD:291255	21/101 (21%)
		PTKc_EphR	736..1002	CDD:270629	80/290 (28%)
		Pkinase_Tyr	741..999	CDD:285015	78/282 (28%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G56140	NP_564709.2	leucine-rich repeat	124..147	CDD:275380
		leucine-rich repeat	148..171	CDD:275380	0/5 (0%)
		leucine-rich repeat	172..195	CDD:275380	3/22 (14%)
		leucine-rich repeat	196..243	CDD:275380	9/64 (14%)
		leucine-rich repeat	220..241	CDD:275380	3/24 (13%)
		leucine-rich repeat	244..267	CDD:275380	4/22 (18%)
		leucine-rich repeat	268..291	CDD:275380	9/37 (24%)
		leucine-rich repeat	292..315	CDD:275380	4/22 (18%)
		leucine-rich repeat	316..339	CDD:275380	3/22 (14%)
		leucine-rich repeat	340..364	CDD:275380	9/28 (32%)
		Malectin	426..612	CDD:288557	35/206 (17%)
		STKc_IRAK	699..961	CDD:270968	78/276 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050