DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and AT1G56130

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_176009.1	Gene:	AT1G56130 / 842065	AraportID:	AT1G56130	Length:	1032	Species:	Arabidopsis thaliana

Alignment Length:	1038	Identity:	209/1038 - (20%)
Similarity:	358/1038 - (34%)	Gaps:	331/1038 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 DCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGEG---------------- 214
            |||.  .|:..|:.| ::..|..|.....||...|.:|  :..:..|:.
plant    90 DCSF--QNSTICRIT-NIKVYAIDVVGPIPPELWTLTY--LTNLNLGQNVLTGSLPPAIGNLTRM 149

  Fly   215 ---RFNQNS-------DVDINTEVKSIAVNKKGVYFAFRDQ-GACISVLAVKVYYITCPAVTE-- 266
               .|..|:       ::.:.|:::.:.::......:..|: |.|..   ::..||....::.
plant   150 QWMTFGINALSGPVPKEIGLLTDLRLLGISSNNFSGSIPDEIGRCTK---LQQMYIDSSGLSGRI 211

  Fly   267 --NFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTG----GCRCKAGYEP 325
              :||:           :::.:.....|.....:.|.::    |.||.||.    |.........
plant   212 PLSFAN-----------LVQLEQAWIADLEVTDQIPDFI----GDWTKLTTLRIIGTGLSGPIPS 261

  Fly   326 NYTNKT-CTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAA 389
            :::|.| .||..||...|               ..:...|.|...
plant   262 SFSNLTSLTELRLGDISS---------------GSSSLDFIKDMK-------------------- 291

  Fly   390 PTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNET 454
              :|::|.:             :|.:.:....|.|.....:.::..:.   |.::.|       .
plant   292 --SLSVLVL-------------RNNNLTGTIPSTIGEHSSLRQVDLSF---NKLHGP-------I 331

  Fly   455 KITLTNLEPVTTYTVQIHAINSVSHINEF---KRHSNESSLVAVSDIVFSNTSLLNIP-LDLNEV 515
            ..:|.||..:|...:..:.:|     ..|   |..|..:..|:.:|:..|..|.:::| |.||.|
plant   332 PASLFNLSQLTHLFLGNNTLN-----GSFPTQKTQSLRNVDVSYNDLSGSLPSWVSLPSLKLNLV 391

  Fly   516 KTGQAEIVFTTESVLLSTVFNLRILAITN---KDADLEWDKPVQSDFPLEFYEVRWFPKVELDAI 577
            ...     ||.|.:      :.|:|...|   |:......|.:.|||                :|
plant   392 ANN-----FTLEGL------DNRVLPGLNCLQKNFPCNRGKGIYSDF----------------SI 429

  Fly   578 NKSALNTKETKAHIVGLL---ENTEYG---FQVR-----CKTNNG-FGSYSNMIYAQTLQS--VG 628
            |...    ..|..:.|.|   |:.::|   |.|.     ..::.| |...||.||..|.||  |.
plant   430 NCGG----PEKRSVTGALFEREDEDFGPASFFVSAGQRWAASSVGLFAGSSNNIYIATSQSQFVN 490

  Fly   629 SVYDDSVQ--------IRFIA-----GAIVTGVLFLVIFIIAT--------------VYFMRSKH 666
            ::..:..|        :|:..     |.....:.|..|.|:.:              :|......
plant   491 TLDSELFQSARLSASSVRYYGLGLENGGYTVTLQFAEIQILGSTSTTWKGLGRRRFDIYVQGRLV 555

  Fly   667 QDDLDKKST-------------------NHLPLPLDYASNE-------------VNSMDTTPIVK 699
            :.|.|.:.|                   |||.:.|.:|...             ::::..||...
plant   556 EKDFDVRRTAGDSTVRAVQRVYKANVSENHLEVHLFWAGKGTCCIPIQGAYGPLISAVSATPDFT 620

  Fly   700 KLHLNVTTPLFGNSRS------------------------------YVD----------PH--TY 722
            ....| ..|..|.:|:                              |.|          |:  ||
plant   621 PTVAN-KPPSKGKNRTGTIVGVIVGVGLLSILAGVVMFTIRKRRKRYTDDEELLGMDVKPYIFTY 684

  Fly   723 EDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDID---VAIKTLKPGSSEK 784
            .:...|.::|.   .:|.      :|.|.||.|.:|.|.         |   ||:|.|..| |.:
plant   685 SELKSATQDFD---PSNK------LGEGGFGPVYKGNLN---------DGRVVAVKLLSVG-SRQ 730

  Fly   785 ARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVML 849
            .:..|:.|...:....|.|::.|.|........|::.||:.|||||..| ..|   :||.|....
plant   731 GKGQFVAEIVAISSVLHRNLVKLYGCCFEGEHRMLVYEYLPNGSLDQAL-FGD---KTLHLDWST 791

  Fly   850 R-----GIASGMSYL---SDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTR-GG 905
            |     |:|.|:.||   :.:..||||:.|.|:|::::|:.:|:||||::..::.....:|| .|
plant   792 RYEICLGVARGLVYLHEEASVRIVHRDVKASNILLDSRLVPQISDFGLAKLYDDKKTHISTRVAG 856

  Fly   906 KIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMS---------YGERPY---WNWSNQDVIKSI 958
            .|  .:.|||.......|..:||:::|||..|::|         ..|:.|   |.|:..:..:.|
plant   857 TI--GYLAPEYAMRGHLTEKTDVYAFGVVALELVSGRPNSDENLEEEKKYLLEWAWNLHEKSRDI 919

  Fly   959 EKGYRLPAPMDCPEA--LYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESD 1019
            |.........:..||  :..:.|.|.|.....||..:.:|:.|........  :|::|...||
plant   920 ELIDDKLTDFNMEEAKRMIGIALLCTQTSHALRPPMSRVVAMLSGDVEIGD--VTSKPGYVSD 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	20/120 (17%)
		FN3	387..476	CDD:238020	11/88 (13%)
		FN3	536..623	CDD:238020	23/101 (23%)
		EphA2_TM	644..736	CDD:291255	25/179 (14%)
		PTKc_EphR	736..1002	CDD:270629	83/291 (29%)
		Pkinase_Tyr	741..999	CDD:285015	81/283 (29%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G56130	NP_176009.1	leucine-rich repeat	125..148	CDD:275380	1/22 (5%)
		leucine-rich repeat	149..172	CDD:275380	2/22 (9%)
		leucine-rich repeat	173..196	CDD:275380	3/22 (14%)
		leucine-rich repeat	197..244	CDD:275380	8/61 (13%)
		leucine-rich repeat	221..242	CDD:275380	3/24 (13%)
		leucine-rich repeat	245..268	CDD:275380	4/22 (18%)
		leucine-rich repeat	269..292	CDD:275380	7/59 (12%)
		leucine-rich repeat	293..316	CDD:275380	5/35 (14%)
		leucine-rich repeat	317..340	CDD:275380	5/32 (16%)
		leucine-rich repeat	341..362	CDD:275380	4/25 (16%)
		Malectin	427..613	CDD:288557	35/205 (17%)
		S_TKc	694..937	CDD:214567	77/267 (29%)
		STKc_IRAK	700..962	CDD:270968	81/277 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050