DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and SRF6

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001077716.1	Gene:	SRF6 / 841811	AraportID:	AT1G53730	Length:	720	Species:	Arabidopsis thaliana

Alignment Length:	652	Identity:	135/652 - (20%)
Similarity:	260/652 - (39%)	Gaps:	154/652 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 DIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRH--SNES 490
            |:.|:...|:...|:..|..|...:.:...:|.|:.:           ::.| |:||..  .:.|
plant   111 DLPYQFPPNLQRLNLANNQFTGAASYSLSQITPLKYL-----------NLGH-NQFKGQIAIDFS 163

  Fly   491 SLVAVSDIVFSNTSLLN-IPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKP 554
            .|.:::.:.||..|..| :|                   ...|::.:|:.|.:.|.......|
plant   164 KLDSLTTLDFSFNSFTNSLP-------------------ATFSSLTSLKSLYLQNNQFSGTVD-- 207

  Fly   555 VQSDFPLEFYEVR------WFPKVELDAI----NKSALNTKET------KAHIVGLLENTEYGFQ 603
            |.:..|||...:.      |.|. .|..|    :.::.||...      ...|.|.......|.:
plant   208 VLAGLPLETLNIANNDFTGWIPS-SLKGITLIKDGNSFNTGPAPPPPPGTPPIRGSPSRKSGGRE 271

  Fly   604 VRC---KTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVL--FLVIFIIATVYFM- 662
            .|.   .|.||                     ||.:....|||| .|::  .||:..:...:|:
plant   272 SRSSDESTRNG---------------------DSKKSGIGAGAI-AGIIISLLVVTALLVAFFLF 314

  Fly   663 ---RSKHQDDLDKKSTNHLPLPLDYASNEV---------NSMDTTPIVKKLHLNVTTPLFGNSRS 715
               :||....:|.:.|::.|..|  |||:.         :|::|..:...|.:|:..|....::|
plant   315 RRKKSKRSSPMDIEKTDNQPFTL--ASNDFHENNSIQSSSSVETKKLDTSLSINLRPPPIDRNKS 377

  Fly   716 YVDPHTYEDPNQAIREFAREIDANY--------------ITIEAIIGGGEFGDVCRGRL---KIP 763
            :.|..:...| .|:::....:.:|.              .:::.::|.|.||.|.|...   |:.
plant   378 FDDEDSTRKP-IAVKKSTVVVPSNVRLYSVADLQIATGSFSVDNLLGEGTFGRVYRAEFDDGKVL 441

  Fly   764 PNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGS 828
            .  |:.||.:  .|..|.::    ||:...|.:...|||||..|.|........:::.|:.:|||
plant   442 A--VKKIDSS--ALPHGMTD----DFIEMVSKIANLDHPNVTKLVGYCAEHGQHLVVYEFHKNGS 498

  Fly   829 LDTFLRVNDGKFQTL---QLIVMLRGIASGMSYLSDM---NYVHRDLAARNVLVNAQLICKIADF 887
            |..||.:::.:.:.|   ..:.:..|.|..:.||.::   :.|.:::.:.|:|::::|...::|.
plant   499 LHDFLHLSEEESKALVWNSRVKIALGTARALEYLHEVCSPSIVDKNIKSANILLDSELNPHLSDS 563

  Fly   888 GLSREIENASDA--YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPY---- 946
            ||:..:..|::.  .|..|      ::|||.....:::..||::|:|||:.|::: |.:|:
plant   564 GLASFLPTANELLNQTDEG------YSAPEVSMSGQYSLKSDIYSFGVVMLELLT-GRKPFDSST 621

  Fly   947 --------WNWSNQD------VIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVS 997
                    ..|:...      :.|.::...:...|:........::..|.|.:...||..:.:|.
plant   622 RSRSEQSLVRWATPQLHDIDALAKMVDPALKGLYPVKSLSRFADVIALCVQPEPEFRPPMSEVVQ 686

  Fly   998 TL 999
            .|
plant   687 AL 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	8/47 (17%)
		FN3	536..623	CDD:238020	21/105 (20%)
		EphA2_TM	644..736	CDD:291255	23/106 (22%)
		PTKc_EphR	736..1002	CDD:270629	66/307 (21%)
		Pkinase_Tyr	741..999	CDD:285015	64/286 (22%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
SRF6	NP_001077716.1	LRRNT_2	28..69	CDD:285463
		LRR_RI	<79..225	CDD:238064	28/146 (19%)
		leucine-rich repeat	98..119	CDD:275380	2/7 (29%)
		LRR_8	118..202	CDD:290566	21/114 (18%)
		leucine-rich repeat	120..143	CDD:275380	3/22 (14%)
		leucine-rich repeat	144..167	CDD:275380	7/34 (21%)
		leucine-rich repeat	168..191	CDD:275380	6/41 (15%)
		leucine-rich repeat	192..212	CDD:275380	5/21 (24%)
		leucine-rich repeat	214..234	CDD:275380	5/20 (25%)
		S_TKc	416..683	CDD:214567	63/281 (22%)
		PKc_like	422..683	CDD:304357	63/275 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050